{"id":"W3175785263","doi":"10.1002/hon.164_2880","title":"ESCALADE: A PHASE 3 STUDY OF ACALABRUTINIB IN COMBINATION WITH R‐CHOP FOR PATIENTS ≤65Y WITH UNTREATED NON‐GERMINAL CENTER B‐CELL–LIKE DIFFUSE LARGE B‐CELL LYMPHOMA","year":2021,"lang":"en","type":"article","venue":"Hematological Oncology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC","funders":"","keywords":"Diffuse large B-cell lymphoma; Medicine; Internal medicine; Population; CHOP; Vincristine; Rituximab; Ibrutinib; Oncology; Gastroenterology; Lymphoma; Cyclophosphamide; Chronic lymphocytic leukemia; Chemotherapy; Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002810978,0.0003230769,0.001214827,0.0001982281,0.00007785754,0.00001349783,0.0001845031,0.000380647,0.0001409996],"category_scores_gemma":[0.0002228433,0.0002125272,0.00009197216,0.0006596736,0.0002222487,0.00006974383,0.0001684356,0.0002825001,0.00001785249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003187955,"about_ca_system_score_gemma":0.002978554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006699055,"about_ca_topic_score_gemma":0.0002386768,"domain_scores_codex":[0.9968926,0.0002999602,0.0007304454,0.0007243477,0.0005822736,0.000770318],"domain_scores_gemma":[0.9976286,0.0007517629,0.0002819424,0.0004598084,0.0006051073,0.0002727328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"nonrandomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.04115165,0.613596,0.321704,0.001490571,0.000279208,0.01218222,0.003154182,0.000006183569,0.001189715,0.0002040139,0.001410065,0.003632256],"study_design_scores_gemma":[0.8971644,0.06030929,0.02345002,0.0002582654,0.000306806,0.001022337,0.002856926,0.005105778,0.007171004,0.00003223804,0.0019353,0.0003876453],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955084,0.00005290211,0.0002110376,0.0002001415,0.00006286977,0.002564948,0.00003116337,0.00004126521,0.00132732],"genre_scores_gemma":[0.9977091,0.00001946507,0.0008498676,0.0002704916,0.00002002855,0.0004070622,0.000224651,0.0000403997,0.0004589684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8560128,"threshold_uncertainty_score":0.8666608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02052770599549982,"score_gpt":0.3369505061010168,"score_spread":0.316422800105517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}