{"id":"W3175785263","doi":"10.1002/hon.164_2880","title":"ESCALADE: A PHASE 3 STUDY OF ACALABRUTINIB IN COMBINATION WITH R‐CHOP FOR PATIENTS ≤65Y WITH UNTREATED NON‐GERMINAL CENTER B‐CELL–LIKE DIFFUSE LARGE B‐CELL LYMPHOMA","year":2021,"lang":"en","type":"article","venue":"Hematological Oncology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC","funders":"","keywords":"Diffuse large B-cell lymphoma; Medicine; Internal medicine; Population; CHOP; Vincristine; Rituximab; Ibrutinib; Oncology; Gastroenterology; Lymphoma; Cyclophosphamide; Chronic lymphocytic leukemia; Chemotherapy; Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001163755,0.001352792,0.001847648,0.0004687374,0.0003654193,0.001237324,0.000953222,0.0009476289,0.004615422],"category_scores_gemma":[0.0005957127,0.0005207341,0.001673678,0.0004737999,0.0007172775,0.0009373164,0.0004875291,0.003913842,0.001191622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001008459,"about_ca_system_score_gemma":0.001136374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001578013,"about_ca_topic_score_gemma":0.003632364,"domain_scores_codex":[0.9996644,0.0001327648,0.00001463438,0.00005834505,0.00003832501,0.00009146223],"domain_scores_gemma":[0.9995335,0.00005933447,0.00007535518,0.00003787214,0.00003080716,0.0002631255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6259221,0.1432401,0.008177506,0.001483957,0.002399852,0.0004059002,0.0006495106,0.003730897,0.04480739,0.0005080542,0.006627665,0.162047],"study_design_scores_gemma":[0.6861747,0.2927303,0.01312264,0.00005824188,0.0005319552,0.0002934153,0.00008138195,0.001473096,0.001690936,0.0002621773,0.003550654,0.00003052376],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919553,0.002225487,0.0003976122,0.0004504417,0.0001105644,0.001748555,0.0008662439,0.0001397254,0.002106015],"genre_scores_gemma":[0.9876335,0.002502111,0.001752605,0.00122651,0.0001666837,0.002581622,0.002104759,0.0000503531,0.001981883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004615422,"threshold_uncertainty_score":0.01544017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02052770599549982,"score_gpt":0.3369505061010168,"score_spread":0.316422800105517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}