{"id":"W3175868284","doi":"10.1016/s2352-3018(21)00071-0","title":"Long-term safety and efficacy of emtricitabine and tenofovir alafenamide vs emtricitabine and tenofovir disoproxil fumarate for HIV-1 pre-exposure prophylaxis: week 96 results from a randomised, double-blind, placebo-controlled, phase 3 trial","year":2021,"lang":"en","type":"article","venue":"The Lancet HIV","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":false,"ca_institutions":"Maple Leaf Medical Clinic","funders":"National Institute of Allergy and Infectious Diseases; AbbVie; Gilead Sciences; Merck; Eli Lilly and Company","keywords":"Emtricitabine; Medicine; Tenofovir alafenamide; Placebo; Pre-exposure prophylaxis; Tenofovir; Human immunodeficiency virus (HIV); Randomized controlled trial; Pharmacology; Internal medicine; Antiretroviral therapy; Men who have sex with men; Virology; Viral load; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001246824,0.0005773759,0.002260278,0.0001888642,0.000293594,0.0001065022,0.000185173,0.0002062519,0.00003083144],"category_scores_gemma":[0.0007758492,0.0003517877,0.0002268454,0.0003768606,0.0002709423,0.0001587195,0.0001791635,0.0003489207,0.000008708332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009792421,"about_ca_system_score_gemma":0.0005371801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001856351,"about_ca_topic_score_gemma":0.00002989102,"domain_scores_codex":[0.9965112,0.0002704157,0.001281351,0.0008807371,0.0004392207,0.0006171262],"domain_scores_gemma":[0.9962609,0.001962981,0.0005386854,0.0007283096,0.0002300312,0.0002790277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9794808,0.00150257,0.004437246,0.0002897923,0.001495303,0.0001585812,0.002568222,0.000008970331,0.001678002,0.00003592193,0.0009884328,0.00735616],"study_design_scores_gemma":[0.9812178,0.00219543,0.01046387,0.0003584867,0.001710993,0.00006798285,0.0001293496,0.0004501952,0.001900105,0.00009830496,0.001012176,0.0003953059],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9737174,0.00447642,0.0003351149,0.01056603,0.0001610416,0.009242033,0.0008872703,0.00008439539,0.0005302785],"genre_scores_gemma":[0.9708597,0.001901393,0.001402294,0.0001560231,0.0009508037,0.000753938,0.001519288,0.00007951459,0.02237703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02184675,"threshold_uncertainty_score":0.9998934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02745232485149335,"score_gpt":0.2935112847525631,"score_spread":0.2660589599010698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}