{"id":"W3175868284","doi":"10.1016/s2352-3018(21)00071-0","title":"Long-term safety and efficacy of emtricitabine and tenofovir alafenamide vs emtricitabine and tenofovir disoproxil fumarate for HIV-1 pre-exposure prophylaxis: week 96 results from a randomised, double-blind, placebo-controlled, phase 3 trial","year":2021,"lang":"en","type":"article","venue":"The Lancet HIV","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":false,"ca_institutions":"Maple Leaf Medical Clinic","funders":"National Institute of Allergy and Infectious Diseases; AbbVie; Gilead Sciences; Merck; Eli Lilly and Company","keywords":"Emtricitabine; Medicine; Tenofovir alafenamide; Placebo; Pre-exposure prophylaxis; Tenofovir; Human immunodeficiency virus (HIV); Randomized controlled trial; Pharmacology; Internal medicine; Antiretroviral therapy; Men who have sex with men; Virology; Viral load; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002632561,0.002002278,0.003910165,0.0003901145,0.0005319088,0.00159339,0.001371364,0.003426248,0.007727325],"category_scores_gemma":[0.003307461,0.0009035772,0.003555753,0.0004360633,0.00144864,0.001693954,0.0003778873,0.004903258,0.001435197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001135771,"about_ca_system_score_gemma":0.0009319285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001178526,"about_ca_topic_score_gemma":0.001923576,"domain_scores_codex":[0.9988097,0.0005918752,0.00009039408,0.0002058595,0.00008598493,0.0002161999],"domain_scores_gemma":[0.9978362,0.0008440848,0.0005622152,0.0001793852,0.0001001791,0.0004780837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9891445,0.00190033,0.0002126682,0.0002956753,0.0008040873,0.00002360948,0.00003481235,0.0001214774,0.001574444,0.00002809136,0.0002022503,0.005658149],"study_design_scores_gemma":[0.941695,0.05400069,0.002160065,0.00004604957,0.0008362482,0.00004236782,0.00002355297,0.0001737544,0.0005415938,0.0001352716,0.0003208433,0.00002448689],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855452,0.01002595,0.0003920553,0.0005594587,0.0004117759,0.0009397596,0.0008293456,0.00007636692,0.001220149],"genre_scores_gemma":[0.9912928,0.003111654,0.0005036792,0.0005324171,0.0003512466,0.001047256,0.0006062503,0.00002554903,0.002529069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007727325,"threshold_uncertainty_score":0.02585047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02745232485149335,"score_gpt":0.2935112847525631,"score_spread":0.2660589599010698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}