{"id":"W3175881592","doi":"10.1126/sciadv.abh3805","title":"Order and disorder—An integrative structure of the full-length human growth hormone receptor","year":2021,"lang":"en","type":"article","venue":"Science Advances","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Deutsches Elektronen-Synchrotron; Novo Nordisk Fonden; Novo Nordisk; H. Lundbeck A/S; Lundbeckfonden; European Synchrotron Radiation Facility; Villum Fonden","keywords":"Human growth hormone; Receptor; Order (exchange); Growth hormone receptor; Growth hormone; Computational biology; Hormone; Biology; Computer science; Bioinformatics; Endocrinology; Genetics; Business","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001446289,0.0001750897,0.0002754655,0.00009440419,0.0003967369,0.00003709373,0.0002828449,0.00005652505,0.0000633388],"category_scores_gemma":[0.0005083327,0.00009966956,0.00004828583,0.001433982,0.001445028,0.0008013543,0.0001345911,0.0002516446,0.000001626534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003347773,"about_ca_system_score_gemma":0.0002944398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003734019,"about_ca_topic_score_gemma":0.0001432326,"domain_scores_codex":[0.9984488,0.00004675137,0.0002527348,0.0004443183,0.0005185067,0.0002888213],"domain_scores_gemma":[0.9987753,0.00003819888,0.0001304885,0.0003698531,0.0005339193,0.0001522264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003683267,0.00007788969,0.02590177,0.00002964116,0.00001158729,0.000001963795,0.001594641,0.000001711982,0.9633567,0.002249392,0.00007187745,0.006665964],"study_design_scores_gemma":[0.001035257,0.001029027,0.1889745,0.000120802,0.00005806819,0.00004481494,0.009072339,0.00003658766,0.7914326,0.005046482,0.002867755,0.000281872],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947397,0.003198282,0.00006688339,0.0006602886,0.0002299241,0.0001889744,0.00002284567,0.00002338493,0.0008697261],"genre_scores_gemma":[0.9973308,0.0003545653,0.001803642,0.0002099933,0.00006170023,0.000003643739,0.00001094401,0.00001067543,0.0002140016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1719242,"threshold_uncertainty_score":0.5324264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007500248595808879,"score_gpt":0.272532836883182,"score_spread":0.2650325882873731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}