{"id":"W3175939027","doi":"10.1016/s1368-8375(21)00375-4","title":"P-88 First-Line Pembrolizumab With or Without Lenvatinib in Recurrent/Metastatic (R/M) Head and Neck Squamous Cell Carcinoma (HNSCC): Phase 3 LEAP-010 Study","year":2021,"lang":"en","type":"article","venue":"Oral Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Pembrolizumab; Lenvatinib; Head and neck squamous-cell carcinoma; Medicine; Oncology; Internal medicine; Head and neck cancer; Basal cell; Head and neck; Phases of clinical research; Cancer research; Cancer; Immunotherapy; Chemotherapy; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002949653,0.0002966499,0.0008904334,0.0001620971,0.00009156122,0.00002302986,0.00009240435,0.0001163752,0.0005373837],"category_scores_gemma":[0.00007252424,0.0002139838,0.00006782186,0.0005348921,0.0001738805,0.00008692584,0.00004828417,0.0003916724,0.00001057149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002875047,"about_ca_system_score_gemma":0.0009128087,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009130628,"about_ca_topic_score_gemma":0.02457252,"domain_scores_codex":[0.9980072,0.0002348722,0.0005391465,0.000549513,0.0002332217,0.0004360444],"domain_scores_gemma":[0.999,0.0001818424,0.0001777021,0.0003623748,0.0001194466,0.0001586903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1784619,0.02254136,0.5578456,0.0006883921,0.0002537552,0.01101832,0.006423477,0.000009228194,0.00527462,0.000009622537,0.002277477,0.2151963],"study_design_scores_gemma":[0.399785,0.1644846,0.3320733,0.0003205276,0.000966928,0.003455824,0.007870548,0.001047595,0.004226081,0.00002790001,0.08471681,0.001024937],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936758,0.002092902,0.00002083462,0.00153565,0.0002448657,0.001108354,0.0000223027,0.00003569376,0.001263618],"genre_scores_gemma":[0.9960929,0.0001665632,0.001070412,0.0007289814,0.00009307226,0.0001099851,0.00004864813,0.00003669224,0.001652818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2257723,"threshold_uncertainty_score":0.9932265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05775824172927307,"score_gpt":0.3728306085500255,"score_spread":0.3150723668207525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}