{"id":"W3175999378","doi":"10.3389/fneur.2021.677551","title":"The ARCA Registry: A Collaborative Global Platform for Advancing Trial Readiness in Autosomal Recessive Cerebellar Ataxias","year":2021,"lang":"en","type":"review","venue":"Frontiers in Neurology","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; McGill University; Montreal Neurological Institute and Hospital","funders":"Medical Research Council; National Institute for Medical Research Development; Universiteit Antwerpen; National Institute of Neurological Disorders and Stroke; Bundesministerium für Bildung und Forschung; Fonds Wetenschappelijk Onderzoek; Radboud Universiteit; ZonMw; Deutsche Forschungsgemeinschaft; Hersenstichting; Eberhard Karls Universität Tübingen; European Commission; University of Auckland; Wellcome Trust; Agence Nationale de la Recherche; Vlaamse regering; E-Rare; Ataxia UK","keywords":"Biobank; Medicine; Clinical trial; Ataxia; Cerebellar ataxia; Disease; Bioinformatics; Pathology; Psychiatry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.2890263,0.001439912,0.003761348,0.01885174,0.001830741,0.01361912,0.006855257,0.003268431,0.02039094],"category_scores_gemma":[0.3327139,0.00165285,0.003551527,0.01897866,0.001613285,0.0108752,0.01965673,0.004216463,0.0162231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003804071,"about_ca_system_score_gemma":0.05874597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003652641,"about_ca_topic_score_gemma":0.004284274,"domain_scores_codex":[0.8146471,0.1053416,0.04867945,0.01028036,0.01701233,0.004039173],"domain_scores_gemma":[0.4358839,0.1960046,0.09153969,0.1171888,0.1033812,0.05600184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003716138,0.000376464,0.0266474,0.007147844,0.001362972,0.0005259761,0.002969853,0.002612039,0.00185366,0.02962339,0.5030269,0.4201374],"study_design_scores_gemma":[0.003095512,0.0007733792,0.0339164,0.009292258,0.001053648,0.0007535699,0.0009366991,0.002885074,0.001868413,0.01599014,0.929058,0.0003768145],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"methods","genre_gemma":"review","genre_scores_codex":[0.04030268,0.03812293,0.2977867,0.09707357,0.007354883,0.05734405,0.2852508,0.05744755,0.1193168],"genre_scores_gemma":[0.08378845,0.01586985,0.5327122,0.01313759,0.004708354,0.0469436,0.2755545,0.01159986,0.01568547],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.2890263,"threshold_uncertainty_score":0.8767571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03714846297688454,"score_gpt":0.334974791243311,"score_spread":0.2978263282664265,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}