{"id":"W3176077537","doi":"10.1128/mbio.00173-21","title":"A Bacterial Inflammation Sensor Regulates c-di-GMP Signaling, Adhesion, and Biofilm Formation","year":2021,"lang":"en","type":"article","venue":"mBio","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Directorate for Biological Sciences; National Institute of General Medical Sciences; Biotechnology and Biological Sciences Research Council; National Institutes of Health; UK Research and Innovation","keywords":"Hypochlorous acid; Biofilm; Microbiology; Bacteria; Innate immune system; Chemistry; Inflammation; Cell biology; Biology; Biochemistry; Receptor; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001362288,0.0003383813,0.0001912459,0.0002443462,0.0002989182,0.0003768535,0.0001580664,0.0003467195,0.001325434],"category_scores_gemma":[0.0001349247,0.0001330027,0.0001828508,0.0001348407,0.0002740669,0.0003770195,0.0003281691,0.0005638056,0.0003817799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003884629,"about_ca_system_score_gemma":0.0003023438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000532546,"about_ca_topic_score_gemma":0.0008479006,"domain_scores_codex":[0.9998142,0.00002175064,0.000007989976,0.00004000341,0.00004547585,0.00007050218],"domain_scores_gemma":[0.9998808,0.000009264927,0.00003552813,0.000005116608,0.00002046979,0.00004875953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001838225,0.0000273086,0.0004331724,0.00003599013,0.000002394807,0.00007509998,0.00003219265,0.00003676004,0.9977306,0.0001849676,0.0001055842,0.001152188],"study_design_scores_gemma":[0.00004419032,0.0004185814,0.08292179,0.00003391345,0.00002274853,0.0003538972,0.0003093421,0.00221556,0.9087195,0.0004449724,0.004496343,0.00001913513],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879107,0.004370031,0.003608855,0.0003990475,0.00006143349,0.00004431341,0.0004723641,0.00009889692,0.00303413],"genre_scores_gemma":[0.9921899,0.001510467,0.001951341,0.0001491054,0.00002029056,0.00003724439,0.0003311405,0.00001502458,0.003795318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001325434,"threshold_uncertainty_score":0.00443399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01317698540011898,"score_gpt":0.2159346187396139,"score_spread":0.2027576333394949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}