{"id":"W3176137669","doi":"10.1016/j.jlr.2021.100094","title":"Lipidomic and transcriptional analysis of the linoleoyl-omega-hydroxyceramide biosynthetic pathway in human psoriatic lesions","year":2021,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; Women's College Hospital; University of Toronto","funders":"Medical Research Council; National Institute of General Medical Sciences; Seventh Framework Programme; National Institutes of Health","keywords":"Omega; Computational biology; Biology; Biochemistry; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001931387,0.000121419,0.0004019212,0.0005127723,0.0001544592,0.00003881085,0.0003740159,0.0001551368,0.00005649014],"category_scores_gemma":[0.0005723596,0.00008194563,0.0003486699,0.00101351,0.0002469677,0.00001034527,0.0001519226,0.000395992,0.000001009842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002520012,"about_ca_system_score_gemma":0.0004151832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002067383,"about_ca_topic_score_gemma":0.0001830587,"domain_scores_codex":[0.997519,0.000708106,0.0006425414,0.0002335533,0.0006100498,0.0002868196],"domain_scores_gemma":[0.9987403,0.0001270808,0.0001988915,0.000368445,0.0004511586,0.0001141904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007220743,0.0002551598,0.005065119,0.00003336449,0.000390179,0.000004679417,0.0002064595,0.000096098,0.9904764,0.0002709948,0.0001000073,0.003029387],"study_design_scores_gemma":[0.0008531581,0.0001348921,0.1104847,0.0001061305,0.0001922426,0.00003359015,0.0003388882,0.00008842433,0.8677207,0.0001132778,0.01980853,0.0001254766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958203,0.002770212,0.00003320323,0.0007654952,0.0002545923,0.00008350407,0.0000264526,0.000001159052,0.0002450634],"genre_scores_gemma":[0.9977703,0.0009298091,0.0001830212,0.00004440726,0.0006498305,0.000002799973,0.000008856861,0.00001254822,0.000398438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1227556,"threshold_uncertainty_score":0.3341646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03534442124890595,"score_gpt":0.3242739502054475,"score_spread":0.2889295289565415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}