{"id":"W3176140146","doi":"10.1097/der.0000000000000770","title":"Rapid Improvement of Itch Associated With Atopic Dermatitis With Abrocitinib Is Partially Independent of Overall Disease Improvement: Results From Pooled Phase 2b and 3 Monotherapy Studies","year":2021,"lang":"en","type":"article","venue":"Dermatitis","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Pfizer","keywords":"Medicine; Atopic dermatitis; Placebo; Antipruritic; Janus kinase inhibitor; Internal medicine; Eczema Area and Severity Index; Dermatology; Randomized controlled trial; Janus kinase; Receptor; Pathology; Alternative medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009405176,0.0002940861,0.0008042001,0.00008814766,0.00009236062,0.00002411986,0.00009061505,0.0000975777,0.0001968987],"category_scores_gemma":[0.0001801575,0.0002333293,0.0001059624,0.0001653572,0.0002493862,0.0001809741,0.00006575234,0.0001418936,0.000002215685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000554063,"about_ca_system_score_gemma":0.0003201869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000130979,"about_ca_topic_score_gemma":0.0002065854,"domain_scores_codex":[0.9978936,0.00009235159,0.0007815256,0.0004153753,0.0005212153,0.0002959273],"domain_scores_gemma":[0.9980748,0.0002250699,0.0005261993,0.0004513637,0.0004839081,0.0002386915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00668813,0.01216939,0.6978474,0.005276274,0.03442843,0.009834385,0.03288929,0.00004694189,0.0234738,0.0004327753,0.07217507,0.1047381],"study_design_scores_gemma":[0.04936967,0.00105726,0.7755835,0.002013235,0.001856527,0.00005953145,0.00162951,0.0003721144,0.1650825,0.000859566,0.001630057,0.0004865343],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875252,0.006032964,0.0001265602,0.003604738,0.00006167912,0.0007053173,0.001676709,0.00004217879,0.0002246299],"genre_scores_gemma":[0.9903297,0.00243154,0.000248702,0.006071473,0.00003046615,0.0001136185,0.0005953331,0.00002931901,0.0001497989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1416087,"threshold_uncertainty_score":0.9514894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01683084688085641,"score_gpt":0.275976346772787,"score_spread":0.2591454998919306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}