{"id":"W3176140146","doi":"10.1097/der.0000000000000770","title":"Rapid Improvement of Itch Associated With Atopic Dermatitis With Abrocitinib Is Partially Independent of Overall Disease Improvement: Results From Pooled Phase 2b and 3 Monotherapy Studies","year":2021,"lang":"en","type":"article","venue":"Dermatitis","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Pfizer","keywords":"Medicine; Atopic dermatitis; Placebo; Antipruritic; Janus kinase inhibitor; Internal medicine; Eczema Area and Severity Index; Dermatology; Randomized controlled trial; Janus kinase; Receptor; Pathology; Alternative medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02019893,0.001339379,0.005120451,0.0008961534,0.0003290027,0.00214557,0.0006996778,0.001070274,0.003031728],"category_scores_gemma":[0.012114,0.0006533707,0.008326587,0.001414631,0.0006372419,0.001229821,0.0006265903,0.001239717,0.000371989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006361894,"about_ca_system_score_gemma":0.001130105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004420611,"about_ca_topic_score_gemma":0.001476468,"domain_scores_codex":[0.9918295,0.00419243,0.00141877,0.001009996,0.001291087,0.0002581208],"domain_scores_gemma":[0.9864268,0.006073556,0.00489577,0.001108153,0.001145184,0.0003504558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.3587316,0.001734277,0.04894566,0.03407075,0.2840374,0.0002942958,0.0003621236,0.002027247,0.02859472,0.0002728746,0.005527187,0.2354018],"study_design_scores_gemma":[0.1378796,0.08484174,0.3633409,0.003456069,0.3798791,0.001905636,0.0002623416,0.001551229,0.008830186,0.0006788912,0.01714944,0.0002248642],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5380358,0.4371882,0.005798402,0.001245898,0.0004884516,0.00320934,0.007146386,0.0003813361,0.006506176],"genre_scores_gemma":[0.9551851,0.03623915,0.001938735,0.001155577,0.0005370362,0.0008679723,0.00341358,0.00008193021,0.0005811183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02019893,"threshold_uncertainty_score":0.1068234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01683084688085641,"score_gpt":0.275976346772787,"score_spread":0.2591454998919306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}