{"id":"W3176153433","doi":"10.3390/cancers13123067","title":"One-Carbon Metabolism Associated Vulnerabilities in Glioblastoma: A Review","year":2021,"lang":"en","type":"review","venue":"Cancers","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Metabolomics; Metabolic pathway; Biology; Purine; Cancer research; Purine metabolism; Reprogramming; Glioma; Glioblastoma; Metabolism; Cell metabolism; Cell; Phenotype; Computational biology; Cell growth; Bioinformatics; Biochemistry; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003083866,0.0007864333,0.001026201,0.002593087,0.0002517997,0.0007918714,0.0006124772,0.0008668607,0.003757437],"category_scores_gemma":[0.0005706963,0.0002544282,0.0004615663,0.002399201,0.0002665569,0.001072471,0.0005568309,0.001206408,0.001580686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005837958,"about_ca_system_score_gemma":0.001068821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00130901,"about_ca_topic_score_gemma":0.002402426,"domain_scores_codex":[0.9999034,0.00001537696,0.00001778702,0.00001901348,0.00003339165,0.000011038],"domain_scores_gemma":[0.9997639,0.0001079813,0.00003827619,0.000005333311,0.00005979696,0.00002467126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008392635,0.0000615602,0.0002212857,0.02907219,0.0001147694,0.000360081,0.00007264176,0.0004059639,0.001801724,0.003179593,0.04858292,0.9160433],"study_design_scores_gemma":[0.00001002538,0.0001024434,0.0008308257,0.004945965,0.0001491775,0.001753306,0.00005059493,0.00007293157,0.0003730382,0.001564741,0.9901286,0.00001839362],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009969186,0.9986907,0.00007398189,0.0002170533,0.0001734227,0.000003590144,0.00002689852,0.000007260429,0.0007074695],"genre_scores_gemma":[0.0003808342,0.9989179,0.0001016354,0.0001327074,0.0001117968,0.000003682684,0.00003250244,0.000001179405,0.0003177228],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003757437,"threshold_uncertainty_score":0.0125699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02720861470556223,"score_gpt":0.3063730652488195,"score_spread":0.2791644505432572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}