{"id":"W3176203625","doi":"10.1002/cmdc.202100262","title":"Polycomb Paralog Chromodomain Inhibitors Active against Both CBX6 and CBX8**","year":2021,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"National Cancer Institute; Canadian Cancer Society Research Institute; National Institutes of Health","keywords":"Chromodomain; Computational biology; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001129622,0.0001753368,0.0001625373,0.00002458565,0.00008589797,0.00003233488,0.00008391352,0.000210022,0.00001923009],"category_scores_gemma":[0.0001193085,0.0001819944,0.00007728997,0.0001031498,0.0001017609,0.000004753,0.0001465874,0.0001089637,0.000007271192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002135435,"about_ca_system_score_gemma":0.0000951859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006345988,"about_ca_topic_score_gemma":0.00001741478,"domain_scores_codex":[0.9989673,0.00004375799,0.0001825261,0.0004284648,0.0001225225,0.0002554032],"domain_scores_gemma":[0.9993845,0.00001979057,0.00007297115,0.0003145276,0.00007055455,0.0001376906],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002051866,0.00005050773,0.001481388,0.00001665151,0.00003932013,0.00001182625,0.00007552956,0.000004860963,0.9866844,0.00005382362,0.0006259303,0.01093522],"study_design_scores_gemma":[0.0005314636,0.00005691275,0.003709111,0.00001371048,0.00001446363,0.000006959805,0.000130905,0.00002293738,0.9751275,0.0003979853,0.01976763,0.0002204966],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988183,0.004653609,0.0003034913,0.0003428938,0.0001487079,0.0000937268,0.00001752696,0.00001505258,0.006241941],"genre_scores_gemma":[0.9960898,0.001153001,0.0009056812,0.0003055389,0.0003529413,0.00001511205,0.0003062922,0.00002923808,0.0008423841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01914169,"threshold_uncertainty_score":0.7421514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008711970215550585,"score_gpt":0.2371497978025521,"score_spread":0.2284378275870015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}