{"id":"W3176203625","doi":"10.1002/cmdc.202100262","title":"Polycomb Paralog Chromodomain Inhibitors Active against Both CBX6 and CBX8**","year":2021,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"National Cancer Institute; Canadian Cancer Society Research Institute; National Institutes of Health","keywords":"Chromodomain; Computational biology; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001452269,0.0004199703,0.0003319337,0.0002270048,0.0001335344,0.0002096385,0.0003314467,0.0002018883,0.001705304],"category_scores_gemma":[0.00006373414,0.00009249255,0.0001772144,0.000167397,0.0001500105,0.0001375697,0.0001208552,0.000684098,0.000343895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002942213,"about_ca_system_score_gemma":0.0002280127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006807181,"about_ca_topic_score_gemma":0.004135957,"domain_scores_codex":[0.9999192,0.000009553599,0.000006379174,0.00001401651,0.00002775362,0.00002301768],"domain_scores_gemma":[0.9999466,0.00001137689,0.000009923327,0.000005382597,0.000007879632,0.00001892103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002298793,0.00028833,0.0001928079,0.0001089529,0.00002666946,0.00006494039,0.0000199196,0.0003268507,0.9877216,0.0002790252,0.0003560715,0.01038495],"study_design_scores_gemma":[0.0001393004,0.00188069,0.001678298,0.000008747997,0.00003716812,0.0003088829,0.00001283534,0.0009912911,0.9857429,0.00006059673,0.009132075,0.000007309977],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9556686,0.01942439,0.009819616,0.000333102,0.0002264233,0.0003611928,0.0009781127,0.0003443389,0.01284422],"genre_scores_gemma":[0.9719566,0.007094474,0.008164152,0.00014636,0.00005506279,0.0001729391,0.001391973,0.00002658438,0.01099195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001705304,"threshold_uncertainty_score":0.005704761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008711970215550585,"score_gpt":0.2371497978025521,"score_spread":0.2284378275870015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}