{"id":"W3176209069","doi":"10.1096/fasebj.2018.32.1_supplement.917.4","title":"Mesenchymal Stromal Cell Microparticles Enhance Lung Endothelial Barrier Through CD44 and the S1P/ceramide Rheostat","year":2018,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"","keywords":"Mesenchymal stem cell; Barrier function; Matrigel; Acid sphingomyelinase; Sphingosine-1-phosphate; Endothelial stem cell; Cancer research; Chemistry; Cell biology; Medicine; Pharmacology; Sphingomyelin; Angiogenesis; Sphingosine; Biology; Biochemistry; Membrane; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001067094,0.0003332645,0.000147657,0.0002033281,0.00007813666,0.0002050482,0.0001041173,0.0002512043,0.001243216],"category_scores_gemma":[0.00008520672,0.00006890722,0.0002291643,0.00006688636,0.000116845,0.000153553,0.0001519565,0.0003041647,0.00030919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000158154,"about_ca_system_score_gemma":0.0001204618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002175616,"about_ca_topic_score_gemma":0.0002783028,"domain_scores_codex":[0.9999245,0.00001447112,0.00000841753,0.000009854715,0.00002516641,0.00001751548],"domain_scores_gemma":[0.9999427,0.00001068839,0.00001664593,0.000003483548,0.00000885364,0.00001771381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001241477,0.00003470082,0.00008385343,0.00005811333,0.000004808604,0.00004184429,0.000006739165,0.00005459518,0.9971661,0.00006705786,0.00005696622,0.002301229],"study_design_scores_gemma":[0.00002961689,0.0003656668,0.001629357,0.000007451394,0.00001598481,0.0001635593,0.00001014302,0.0005908523,0.9956364,0.00003704891,0.001511609,0.000002201844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988237,0.00412532,0.004629995,0.0002172248,0.00007119768,0.00006721519,0.0002681591,0.0001457241,0.002238198],"genre_scores_gemma":[0.9934044,0.001166877,0.002979772,0.0000879697,0.00002584071,0.00005084925,0.0001793981,0.00001192441,0.002092989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001243216,"threshold_uncertainty_score":0.004158914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005392765311262162,"score_gpt":0.2436592334266889,"score_spread":0.2382664681154268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}