{"id":"W3176222481","doi":"10.1096/fasebj.22.1_supplement.921.19","title":"Coordinate Induction of ATP‐Binding Cassette (ABC) Proteins by Bile Acids via Nrf2 is Mediated by Mitogen Activated Protein Kinases (MAPK)","year":2008,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"MAPK/ERK pathway; ATP-binding cassette transporter; Kinase; Biochemistry; Cell biology; Protein kinase A; Multidrug resistance-associated protein 2; Biology; Bile acid; Mitogen-activated protein kinase; Chemistry; Transporter; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002725581,0.0006099423,0.0002921445,0.0002191594,0.0002091521,0.0002904423,0.0001412954,0.000223099,0.007100337],"category_scores_gemma":[0.0001454196,0.0001196654,0.0003176354,0.0001539588,0.0002112322,0.0002793792,0.0002647336,0.0003620599,0.001614422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002320501,"about_ca_system_score_gemma":0.0002194782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005278941,"about_ca_topic_score_gemma":0.0008785663,"domain_scores_codex":[0.999811,0.00003623354,0.00002145166,0.00004349278,0.0000472338,0.00004061248],"domain_scores_gemma":[0.9998711,0.00001351496,0.00003441087,0.00001541201,0.0000444038,0.00002096651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001452106,0.00002646793,0.0001423206,0.0001463893,0.000005717469,0.00004942169,0.00001056999,0.0000302199,0.9975055,0.0001395508,0.0001565853,0.001642086],"study_design_scores_gemma":[0.00006447214,0.0003839992,0.02004609,0.00002467042,0.000032924,0.0005504271,0.00007127085,0.001194835,0.9667662,0.0003073322,0.01054342,0.00001434637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.959229,0.01044939,0.01253571,0.002222843,0.000295556,0.0001428634,0.003876424,0.0004814342,0.01076678],"genre_scores_gemma":[0.9710438,0.005491919,0.007111262,0.0001929093,0.0000907598,0.0001653389,0.002410433,0.00004386313,0.01344972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007100337,"threshold_uncertainty_score":0.02375299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01706066459370785,"score_gpt":0.2326415324551636,"score_spread":0.2155808678614558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}