{"id":"W3176231206","doi":"10.1128/aac.00398-21","title":"Amaryllidaceae Alkaloid Cherylline Inhibits the Replication of Dengue and Zika Viruses","year":2021,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique; Université du Québec à Trois-Rivières","funders":"Canada Research Chairs; Universität Heidelberg; Aix-Marseille Université","keywords":"Virology; Dengue fever; Amaryllidaceae; Flavivirus; Zika virus; Biology; Dengue virus; Alkaloid; Viral replication; Virus; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001071668,0.0001683744,0.000248495,0.0000130308,0.0001076726,0.00005495765,0.000121822,0.0001141234,0.0006008019],"category_scores_gemma":[0.00004115699,0.0001239312,0.00007755579,0.0001040416,0.0001481624,0.00005715474,0.00007583388,0.0001200409,0.000002834576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001128901,"about_ca_system_score_gemma":0.00002160499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005038509,"about_ca_topic_score_gemma":0.00001001504,"domain_scores_codex":[0.9990251,0.00001495596,0.0002814445,0.0003950468,0.0001078925,0.0001755258],"domain_scores_gemma":[0.9992645,0.00007450655,0.0001248527,0.0004084035,0.00006764667,0.00006004657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002731804,0.0001303629,0.009402088,0.00008652062,0.00006350189,0.0000020059,0.0001987985,3.641797e-7,0.9617439,0.00005544696,0.004473689,0.02381601],"study_design_scores_gemma":[0.0005629258,0.000005560916,0.00401266,0.00008164897,0.00002429083,0.00002388924,0.00005843143,0.00002426263,0.9089928,0.0000968011,0.08597453,0.0001422237],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953388,0.0004479647,0.00001700898,0.003025271,0.00002279028,0.00005464838,0.00003297546,0.00002408763,0.001036449],"genre_scores_gemma":[0.9903602,0.004207039,0.0002401474,0.004215964,0.0001505511,0.000004634888,0.00002972562,0.00002700998,0.0007647393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08150084,"threshold_uncertainty_score":0.657836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01680420786430837,"score_gpt":0.2503179810964988,"score_spread":0.2335137732321905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}