{"id":"W3176231206","doi":"10.1128/aac.00398-21","title":"Amaryllidaceae Alkaloid Cherylline Inhibits the Replication of Dengue and Zika Viruses","year":2021,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique; Université du Québec à Trois-Rivières","funders":"Canada Research Chairs; Universität Heidelberg; Aix-Marseille Université","keywords":"Virology; Dengue fever; Amaryllidaceae; Flavivirus; Zika virus; Biology; Dengue virus; Alkaloid; Viral replication; Virus; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007270172,0.0002305768,0.0001713876,0.0001497543,0.0001071636,0.0001656101,0.0001227118,0.0001732571,0.001828127],"category_scores_gemma":[0.0001317974,0.00007247419,0.0001251529,0.00009754457,0.00009240597,0.0001486435,0.0001414521,0.0002913934,0.000503031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001236563,"about_ca_system_score_gemma":0.0001699795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003337538,"about_ca_topic_score_gemma":0.000869739,"domain_scores_codex":[0.9999421,0.00001227652,0.000005613701,0.00001110893,0.00001664841,0.00001221271],"domain_scores_gemma":[0.9999413,0.00001768764,0.00001007651,0.000007403863,0.00001077782,0.00001265601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006787481,0.00001298132,0.00004369532,0.00004925618,0.000003861753,0.00001906235,0.000005827538,0.00004760634,0.9968061,0.00007340844,0.00003471401,0.002835697],"study_design_scores_gemma":[0.00002280147,0.0005083803,0.001515165,0.000007331102,0.00001067559,0.0001904147,0.000009691797,0.000483383,0.991581,0.00004886062,0.005618183,0.00000405079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9759136,0.007942342,0.005695459,0.0002262649,0.00009029874,0.00006725117,0.0007606015,0.0001997293,0.009104524],"genre_scores_gemma":[0.9911078,0.001764652,0.00360966,0.000051475,0.00001340569,0.00002517273,0.0003701882,0.00001992256,0.00303775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001828127,"threshold_uncertainty_score":0.006115735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01680420786430837,"score_gpt":0.2503179810964988,"score_spread":0.2335137732321905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}