{"id":"W3176308859","doi":"10.1158/2159-8290.cd-20-1647","title":"Genomic and Transcriptomic Analyses of Breast Cancer Primaries and Matched Metastases in AURORA, the Breast International Group (BIG) Molecular Screening Initiative","year":2021,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":177,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Cilag; National Cancer Institute; Genentech; Fondation contre le Cancer; Servier; European Organisation for Research and Treatment of Cancer; National Institute for Health and Care Research; Cancer Research UK; G1 Therapeutics; Koning Boudewijnstichting; Puma Biotechnology; Sanofi; Breast Cancer Research Foundation; PTC Therapeutics; Fondation Cancer; National Breast Cancer Foundation; Clovis Oncology; Eli Lilly and Company; AstraZeneca; National Cancer Research Institute; GlaxoSmithKline; Pfizer; Cancer Research Institute","keywords":"Breast cancer; Transcriptome; Oncology; Medicine; Cancer; Computational biology; Biology; Internal medicine; Genetics; Bioinformatics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007938778,0.0001517193,0.0002156637,0.00004523914,0.00004433146,0.00008215252,0.0001181174,0.00005318471,0.00002146729],"category_scores_gemma":[0.00001884196,0.0001292034,0.00006922552,0.00009783776,0.0002069542,0.00001817596,0.0001545111,0.00007915705,7.862619e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003930329,"about_ca_system_score_gemma":0.0002430865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001720564,"about_ca_topic_score_gemma":0.003645916,"domain_scores_codex":[0.9991553,0.00005433934,0.0002178216,0.0003191455,0.00009672836,0.0001566543],"domain_scores_gemma":[0.9995722,0.00003676965,0.0001014573,0.000167827,0.00007970508,0.00004209591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003131827,0.00005015368,0.08890182,0.00005230021,0.0004601041,0.00001949282,0.0002143064,0.0009413795,0.8991895,0.0002753128,0.0001143842,0.009468069],"study_design_scores_gemma":[0.001661291,0.00004556566,0.8233374,0.0001330837,0.0002603598,0.00009543864,0.001103913,0.000166763,0.1712434,0.0002732252,0.001352787,0.0003268003],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9699823,0.02451767,0.001766275,0.000943567,0.0001566108,0.00010566,0.002464433,0.000002258209,0.0000612854],"genre_scores_gemma":[0.9879353,0.01084194,0.0001797584,0.0006583544,0.0001302369,0.00005016068,0.0001605264,0.00001862089,0.00002511336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7344356,"threshold_uncertainty_score":0.5268762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0225287982106395,"score_gpt":0.2862496692165856,"score_spread":0.2637208710059461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}