{"id":"W3176308859","doi":"10.1158/2159-8290.cd-20-1647","title":"Genomic and Transcriptomic Analyses of Breast Cancer Primaries and Matched Metastases in AURORA, the Breast International Group (BIG) Molecular Screening Initiative","year":2021,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":177,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Cilag; National Cancer Institute; Genentech; Fondation contre le Cancer; Servier; European Organisation for Research and Treatment of Cancer; National Institute for Health and Care Research; Cancer Research UK; G1 Therapeutics; Koning Boudewijnstichting; Puma Biotechnology; Sanofi; Breast Cancer Research Foundation; PTC Therapeutics; Fondation Cancer; National Breast Cancer Foundation; Clovis Oncology; Eli Lilly and Company; AstraZeneca; National Cancer Research Institute; GlaxoSmithKline; Pfizer; Cancer Research Institute","keywords":"Breast cancer; Transcriptome; Oncology; Medicine; Cancer; Computational biology; Biology; Internal medicine; Genetics; Bioinformatics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001548001,0.0001730508,0.0002211708,0.0005376547,0.0001982577,0.0002909317,0.0001026844,0.0001425358,0.001284855],"category_scores_gemma":[0.000378394,0.0000774176,0.0001782283,0.0005242527,0.0001141984,0.00006416174,0.0002906964,0.0001685952,0.0002356529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001721308,"about_ca_system_score_gemma":0.0001479566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008948598,"about_ca_topic_score_gemma":0.002041845,"domain_scores_codex":[0.9998411,0.0000196794,0.00001229122,0.00006000072,0.00003687453,0.00003006852],"domain_scores_gemma":[0.9998603,0.00002690851,0.00004174234,0.00001435246,0.00002804357,0.00002864756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001797272,0.0001098291,0.4914345,0.0002006275,0.0002538001,0.000586231,0.0002144492,0.0004339096,0.4782192,0.0001218102,0.00132123,0.025307],"study_design_scores_gemma":[0.00002866407,0.0002628286,0.9666676,0.0000122613,0.0001405873,0.001526664,0.0001472838,0.0005817629,0.02828556,0.00009771634,0.002242714,0.000006309092],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951089,0.0003861047,0.000377546,0.00004567155,0.000005025372,0.00001348219,0.003614118,0.00002205013,0.0004272253],"genre_scores_gemma":[0.9935148,0.0001319384,0.0008076215,0.00005466705,0.00000718971,0.00002566551,0.005012599,0.000008479761,0.0004370078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001284855,"threshold_uncertainty_score":0.004298329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0225287982106395,"score_gpt":0.2862496692165856,"score_spread":0.2637208710059461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}