{"id":"W3176345696","doi":"10.1101/2021.06.25.449796","title":"Global cellular response to chemical perturbation of PLK4 activity and abnormal centrosome number","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sinai Health System; Lunenfeld-Tanenbaum Research Institute","funders":"Ministry of Education, India; Krembil Foundation","keywords":"Centrosome; Centriole; Cell biology; Centrosome cycle; Mitosis; Biology; Cell cycle; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001135917,0.0002659375,0.0002972083,0.0002377534,0.000118418,0.0002875156,0.0002473913,0.0002642147,0.001866315],"category_scores_gemma":[0.0001031669,0.0001105965,0.000159924,0.0002264609,0.0002271841,0.0001341108,0.0002040424,0.0004602704,0.0003533382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005269872,"about_ca_system_score_gemma":0.0001578822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001141759,"about_ca_topic_score_gemma":0.001173419,"domain_scores_codex":[0.9998384,0.00001772649,0.00001275676,0.00004881496,0.00003941167,0.00004286804],"domain_scores_gemma":[0.9998873,0.00002151723,0.0000317967,0.00001669826,0.00001097497,0.0000316025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002277891,0.0000273006,0.0001917661,0.00002570906,0.000007485509,0.00002682139,0.000005287095,0.0001870803,0.998548,0.00004294118,0.00006816885,0.0006416562],"study_design_scores_gemma":[0.000007476782,0.00008449466,0.002722255,0.000001586845,0.00000512239,0.00002674402,0.00001008713,0.0006523281,0.9960113,0.00001864921,0.0004568749,0.000003149646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930277,0.00101559,0.001771279,0.0001212517,0.00004630531,0.00002031043,0.002055098,0.0001695229,0.001772982],"genre_scores_gemma":[0.9935732,0.0004366005,0.001063004,0.00006864346,0.00000766355,0.00003392641,0.001444781,0.00004981336,0.003322229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001866315,"threshold_uncertainty_score":0.006243408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005504970913729431,"score_gpt":0.2123972705016718,"score_spread":0.2068922995879424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}