{"id":"W3176355311","doi":"10.1096/fasebj.2019.33.1_supplement.lb72","title":"Biphenylindanone A, a prototypical mGlu <sub>2</sub> positive allosteric modulator, alleviates dyskinesia and psychosis in the parkinsonian marmoset","year":2019,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Weston Brain Institute","keywords":"Dyskinesia; MPTP; Marmoset; Allosteric modulator; Benserazide; Psychosis; Pharmacology; Medicine; Parkinson's disease; Neuroscience; Callithrix; Levodopa; Psychology; Allosteric regulation; Internal medicine; Receptor; Psychiatry; Biology; Disease; Primate","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008294703,0.0003308528,0.0003757994,0.0002307226,0.0003450832,0.0001920829,0.0002100134,0.0003560788,0.00125062],"category_scores_gemma":[0.0001056208,0.0001331501,0.0001989184,0.0001345635,0.0003290708,0.0002031537,0.0002137858,0.0005248219,0.0002047725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000267752,"about_ca_system_score_gemma":0.0001964516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0015548,"about_ca_topic_score_gemma":0.00398621,"domain_scores_codex":[0.9999138,0.00001115788,0.000007557478,0.00001461668,0.00002375161,0.0000291789],"domain_scores_gemma":[0.9999239,0.000003789017,0.00002570207,0.000006097625,0.000006860826,0.00003353985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001162356,0.0002010699,0.000794309,0.00004046635,0.00001274064,0.0001042811,0.00003586847,0.00007805465,0.9951121,0.00004489806,0.00004722413,0.002366709],"study_design_scores_gemma":[0.0006043871,0.02463818,0.06663952,0.00001300831,0.0001121823,0.001699513,0.000270878,0.00166525,0.9009669,0.000182217,0.003178785,0.00002930204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992369,0.0002092598,0.0001131527,0.00002871091,0.000004676881,0.00001775473,0.0000616338,0.0000136576,0.0003143292],"genre_scores_gemma":[0.9975338,0.0003361251,0.000999664,0.00008695466,0.000007481223,0.00007312986,0.0001857633,0.000003876975,0.0007731537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0015548,"threshold_uncertainty_score":0.004183769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02610905799459882,"score_gpt":0.29083161162032,"score_spread":0.2647225536257211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}