{"id":"W3176370909","doi":"10.1016/s2352-3026(21)00134-4","title":"CPX-351 versus 7+3 cytarabine and daunorubicin chemotherapy in older adults with newly diagnosed high-risk or secondary acute myeloid leukaemia: 5-year results of a randomised, open-label, multicentre, phase 3 trial","year":2021,"lang":"en","type":"article","venue":"The Lancet Haematology","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":211,"is_retracted":false,"has_abstract":false,"ca_institutions":"Leukemia & Lymphoma Society of Canada","funders":"Celator Pharmaceuticals; Jazz Pharmaceuticals","keywords":"Medicine; Cytarabine; Daunorubicin; Internal medicine; Myeloid leukemia; Chemotherapy; Myeloid leukaemia; Chemotherapy regimen; Oncology; Pediatrics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001491569,0.001447227,0.002538983,0.0003139108,0.0003257286,0.0009928514,0.0007406037,0.001360895,0.004290611],"category_scores_gemma":[0.001482883,0.0004340556,0.002006727,0.0003703954,0.001002082,0.00101831,0.0005169144,0.00309923,0.0006435596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008122006,"about_ca_system_score_gemma":0.0007970473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001464374,"about_ca_topic_score_gemma":0.003000318,"domain_scores_codex":[0.9994604,0.0002914511,0.00002900675,0.00009714762,0.00003263199,0.00008940446],"domain_scores_gemma":[0.9991485,0.0002391875,0.000206947,0.0000503987,0.00003793916,0.0003170515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9796287,0.002270392,0.0007061759,0.0003877962,0.000949298,0.00003403144,0.00006181576,0.0003493178,0.001975166,0.00009218411,0.0004795104,0.01306562],"study_design_scores_gemma":[0.9163465,0.0764741,0.005206044,0.00003892129,0.0005861479,0.00004947732,0.00004209623,0.0003713426,0.0002118887,0.0001594584,0.0004971536,0.00001681382],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941339,0.003257378,0.0002255321,0.0003943533,0.0002436233,0.0006306386,0.0003710103,0.00004336733,0.0007001265],"genre_scores_gemma":[0.993192,0.002251303,0.0006174928,0.0006827524,0.0002468578,0.0007747348,0.0007562758,0.00001336128,0.00146521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004290611,"threshold_uncertainty_score":0.01435351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03108454719582305,"score_gpt":0.3381754923427316,"score_spread":0.3070909451469086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}