{"id":"W3176428296","doi":"10.1101/2021.06.29.450442","title":"Epigenetic regulation of frog innate immunity: Discovery of frog microRNAs associated with antiviral responses and ranavirus infection using a <i>Xenopus laevis</i> skin epithelial-like cell line","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; University of Waterloo","keywords":"Biology; Innate immune system; Xenopus; microRNA; Ranavirus; Interferon; Cell biology; Epigenetics; Wnt signaling pathway; Immunity; Amphibian; Signal transduction; Virus; Virology; Immune system; Immunology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001763415,0.0002467967,0.0002111398,0.0001986203,0.0001413181,0.0002717069,0.0001200356,0.0001750043,0.0008185979],"category_scores_gemma":[0.0001306995,0.0001463131,0.0003117313,0.000131436,0.0001386228,0.0001321351,0.0001351066,0.0002457047,0.0002960302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002013713,"about_ca_system_score_gemma":0.00009727445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003204687,"about_ca_topic_score_gemma":0.0005004776,"domain_scores_codex":[0.9998655,0.00002803468,0.00001491281,0.00004224525,0.00002804158,0.00002127527],"domain_scores_gemma":[0.9998672,0.00002793369,0.00005374894,0.00001724921,0.00001526893,0.00001854572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001486749,0.000002563506,0.0002216908,0.000007440905,0.000001561656,0.00001015314,0.000003702767,0.0000111193,0.9995362,0.000009480962,0.000004440181,0.0001767614],"study_design_scores_gemma":[0.000005517244,0.0002421678,0.02095961,0.000003261059,0.00001731026,0.0003102373,0.00002976371,0.0006291247,0.9766148,0.00001513239,0.001167547,0.000005656717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937409,0.0007148297,0.00377293,0.00004351263,0.00001438557,0.000034385,0.0007249567,0.00007387403,0.000880303],"genre_scores_gemma":[0.9919709,0.0004280618,0.00468755,0.00005397645,0.000008807381,0.00005161858,0.001480617,0.00002656321,0.00129192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008185979,"threshold_uncertainty_score":0.002738535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01288134077538451,"score_gpt":0.2222866907137935,"score_spread":0.209405349938409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}