{"id":"W3176532045","doi":"10.1016/s0140-6736(21)00933-8","title":"Ciltacabtagene autoleucel, a B-cell maturation antigen-directed chimeric antigen receptor T-cell therapy in patients with relapsed or refractory multiple myeloma (CARTITUDE-1): a phase 1b/2 open-label study","year":2021,"lang":"en","type":"article","venue":"The Lancet","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1664,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Janssen Research and Development","keywords":"Chimeric antigen receptor; Antigen; Refractory (planetary science); Medicine; Open label; Multiple myeloma; Receptor; Immunology; Cell; Immunotherapy; Cancer research; Biology; Internal medicine; Immune system; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001113538,0.001394685,0.001943399,0.000445864,0.0003266248,0.001265964,0.0007750682,0.00150438,0.002784077],"category_scores_gemma":[0.0005202004,0.0004319131,0.001336878,0.0004417047,0.0008975335,0.001021408,0.0002469328,0.002864338,0.0007474512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009565664,"about_ca_system_score_gemma":0.001193985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001524136,"about_ca_topic_score_gemma":0.003522359,"domain_scores_codex":[0.9996777,0.0001216361,0.0000114658,0.00005744498,0.00003291579,0.00009897756],"domain_scores_gemma":[0.9996269,0.00008801783,0.00005506728,0.00003003726,0.0000197203,0.0001803807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7295913,0.0457415,0.005399034,0.001272269,0.00182025,0.0002488703,0.0002609945,0.002330856,0.03834232,0.0006114084,0.006060163,0.1683211],"study_design_scores_gemma":[0.6476842,0.3369334,0.006838219,0.00004473209,0.0006659163,0.0002032377,0.0000652805,0.001175793,0.002967411,0.0002465277,0.003136587,0.00003869446],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899645,0.00499011,0.0004559911,0.0006738235,0.0002200193,0.000803837,0.000910017,0.0001385209,0.001843228],"genre_scores_gemma":[0.9880559,0.00369005,0.0009773467,0.001203517,0.0002144084,0.0008924322,0.001814321,0.0000422532,0.0031098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002784077,"threshold_uncertainty_score":0.009313643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06200547005268376,"score_gpt":0.3469799739780643,"score_spread":0.2849745039253806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}