{"id":"W3176533716","doi":"10.1016/j.jcmgh.2021.06.011","title":"Prebiotic Enriched Exclusive Enteral Nutrition Suppresses Colitis via Gut Microbiome Modulation and Expansion of Anti-inflammatory T Cells in a Mouse Model of Colitis","year":2021,"lang":"en","type":"article","venue":"Cellular and Molecular Gastroenterology and Hepatology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; CH.I.L.D. Foundation; Crohn's and Colitis Canada; Michael Smith Health Research BC","keywords":"Colitis; Inflammatory bowel disease; Immune system; Medicine; Gut flora; Immunology; Bifidobacterium; Ulcerative colitis; FOXP3; Microbiome; Adoptive cell transfer; Gastroenterology; Internal medicine; Microbiology; T cell; Lactobacillus; Biology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000992358,0.0001964028,0.0004529201,0.0001363132,0.00004864261,0.000006889628,0.00006681107,0.0003111618,0.000004887132],"category_scores_gemma":[0.00001117367,0.0002263073,0.00006353486,0.00004469052,0.0003297019,0.00001040556,0.0001777953,0.000116313,1.659026e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008697568,"about_ca_system_score_gemma":0.00006069569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002895449,"about_ca_topic_score_gemma":0.00009414332,"domain_scores_codex":[0.9984888,0.0002572635,0.0004218709,0.0004575673,0.0000500892,0.0003243927],"domain_scores_gemma":[0.999428,0.00001254823,0.0001607494,0.0002108379,0.00009495158,0.00009285851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004589529,0.0001640617,0.03091074,0.0004995404,0.0000511357,0.00004196742,0.0001708801,0.00005753713,0.9674355,0.0001286483,0.00001737353,0.00006359443],"study_design_scores_gemma":[0.002483699,0.0005067285,0.01591398,0.0000432647,0.00004606856,0.0002155362,0.00008144926,0.00313429,0.977216,0.0001932346,0.00003481916,0.0001309424],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881811,0.001364793,0.009867229,0.0001178224,0.00005794508,0.0002972297,0.0001035192,0.000004638651,0.00000568566],"genre_scores_gemma":[0.9964102,0.001772534,0.001202411,0.0002486028,0.00001339141,0.00001514058,0.0002947593,0.0000179789,0.00002497326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01499676,"threshold_uncertainty_score":0.9228544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005429201749777703,"score_gpt":0.2105895056451305,"score_spread":0.2051603038953528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}