{"id":"W3176533716","doi":"10.1016/j.jcmgh.2021.06.011","title":"Prebiotic Enriched Exclusive Enteral Nutrition Suppresses Colitis via Gut Microbiome Modulation and Expansion of Anti-inflammatory T Cells in a Mouse Model of Colitis","year":2021,"lang":"en","type":"article","venue":"Cellular and Molecular Gastroenterology and Hepatology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; CH.I.L.D. Foundation; Crohn's and Colitis Canada; Michael Smith Health Research BC","keywords":"Colitis; Inflammatory bowel disease; Immune system; Medicine; Gut flora; Immunology; Bifidobacterium; Ulcerative colitis; FOXP3; Microbiome; Adoptive cell transfer; Gastroenterology; Internal medicine; Microbiology; T cell; Lactobacillus; Biology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002597874,0.0006972928,0.0004686597,0.0005774235,0.0002106319,0.0003448838,0.000267932,0.0005758135,0.001472166],"category_scores_gemma":[0.0001176487,0.0002647833,0.00032481,0.0002286261,0.0004579331,0.0003325567,0.0002307174,0.001491716,0.000276199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002117844,"about_ca_system_score_gemma":0.0003178395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002336829,"about_ca_topic_score_gemma":0.0006955373,"domain_scores_codex":[0.9997577,0.00004526556,0.00002656456,0.00005073139,0.00005576612,0.00006397496],"domain_scores_gemma":[0.9997932,0.00001266175,0.0000644731,0.00001991973,0.00001435016,0.00009545598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002079956,0.0009773951,0.0004117452,0.00009995218,0.00001139211,0.00009574166,0.00003169162,0.0001156568,0.9932373,0.00008304333,0.00009470957,0.002761398],"study_design_scores_gemma":[0.0006185757,0.01865471,0.01268617,0.0000791164,0.0001282602,0.0007241718,0.0001685068,0.001215007,0.9603336,0.0001673681,0.005205739,0.00001885933],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958931,0.0009698523,0.001291554,0.0001712939,0.00006727594,0.00007735036,0.0003791343,0.0001018985,0.001048444],"genre_scores_gemma":[0.9887903,0.001405841,0.003356357,0.0001934508,0.00004477445,0.0002387441,0.0006548243,0.0000428081,0.005272863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001472166,"threshold_uncertainty_score":0.004924893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005429201749777703,"score_gpt":0.2105895056451305,"score_spread":0.2051603038953528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}