{"id":"W3176536564","doi":"10.1096/fasebj.2019.33.1_supplement.503.9","title":"Aldosterone binding to G Protein Estrogen Receptor‐GPER","year":2019,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; St. Boniface Hospital","funders":"Heart and Stroke Foundation of Canada","keywords":"GPER; Radioligand; Agonist; Aldosterone; Receptor; Binding site; Mineralocorticoid receptor; Biology; Chemistry; Estrogen receptor; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001436316,0.0002893873,0.0002912029,0.0001487545,0.0002229561,0.0003261263,0.0002262242,0.0003509543,0.003359218],"category_scores_gemma":[0.0002310542,0.0001356637,0.0003899702,0.0001623395,0.0001708404,0.0001856961,0.0002711784,0.0004702788,0.001265457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004400017,"about_ca_system_score_gemma":0.0001962302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001647913,"about_ca_topic_score_gemma":0.002128842,"domain_scores_codex":[0.9998025,0.00004055268,0.000008021193,0.00005571142,0.00004197954,0.00005122978],"domain_scores_gemma":[0.9999343,0.00002436467,0.000009636813,0.00001158754,0.000009733185,0.00001026569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001014383,0.00001565092,0.0002386379,0.00005816703,0.00000957198,0.00007595474,0.00002772004,0.00004979244,0.997922,0.0001537024,0.00008561047,0.001261804],"study_design_scores_gemma":[0.00006903632,0.0009731538,0.04867221,0.00003136601,0.00004991252,0.001567309,0.0001516227,0.001931911,0.9280486,0.0003685227,0.01811676,0.00001968284],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868698,0.005001889,0.003154531,0.00029387,0.00005424127,0.00002815887,0.0004493152,0.00006708463,0.004081175],"genre_scores_gemma":[0.9869103,0.002582847,0.001958783,0.000363717,0.00003106724,0.00001970946,0.001346949,0.00002247429,0.006764265],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003359218,"threshold_uncertainty_score":0.01123774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00581371588356286,"score_gpt":0.2221125809188376,"score_spread":0.2162988650352748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}