{"id":"W3176657909","doi":"10.1096/fasebj.2018.32.1_supplement.833.4","title":"INVESTIGATION INTO THE EFFECTS OF TESTOSTERONE ON DRUG METABOLIZING ENZYMES IN HEPATIC AND INTESTINAL HUMAN CELL LINES","year":2018,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"CYP3A4; Testosterone (patch); Drug metabolism; Bioavailability; Cytochrome P450; Internal medicine; Hormone; Endocrinology; Pharmacology; Chemistry; Cell culture; Metabolism; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004002597,0.0002890363,0.0004709465,0.0003620519,0.0002969579,0.0004370869,0.000180754,0.0002025286,0.003181482],"category_scores_gemma":[0.0002662513,0.000130285,0.0004402043,0.000871962,0.0002596621,0.0001493882,0.0001425102,0.0004139052,0.001354924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002270198,"about_ca_system_score_gemma":0.0002952514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003059579,"about_ca_topic_score_gemma":0.00425267,"domain_scores_codex":[0.999422,0.0001716387,0.0000781382,0.00009404739,0.0001536688,0.00008048397],"domain_scores_gemma":[0.9996871,0.00008501086,0.00003118937,0.00007097905,0.0001011814,0.00002451334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005860312,0.0002081928,0.003739048,0.0003349718,0.00003180966,0.000349437,0.0001236828,0.0001769388,0.9862549,0.0001507555,0.0005191894,0.007525124],"study_design_scores_gemma":[0.00004900278,0.00155879,0.02174169,0.00002114073,0.0001168008,0.000992809,0.0002582259,0.0008188718,0.9592725,0.00004439979,0.01510723,0.0000185275],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9429461,0.01645409,0.02014045,0.0005636984,0.0002575078,0.0003025957,0.008929608,0.0004185577,0.009987354],"genre_scores_gemma":[0.9533505,0.00888001,0.01325043,0.0002659217,0.00009204725,0.0002973145,0.01194462,0.00007337415,0.01184579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003181482,"threshold_uncertainty_score":0.01064312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06045401336198806,"score_gpt":0.3719187595688022,"score_spread":0.3114647462068141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}