{"id":"W3176790120","doi":"10.1128/mbio.00788-21","title":"Identification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects","year":2021,"lang":"en","type":"article","venue":"mBio","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; University of Ottawa","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Biology; Viral evolution; Mutation; Selection (genetic algorithm); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Adaptation (eye); Virology; Genetics; Mutation rate; Spike (software development); Coronavirus disease 2019 (COVID-19); Computational biology; RNA; Gene; Medicine; Disease; Infectious disease (medical specialty); Neuroscience; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000324616,0.0001490086,0.0003379257,0.0001211915,0.00005720493,0.00003711261,0.0001012682,0.0001147615,0.000006351524],"category_scores_gemma":[0.0003118791,0.0001238011,0.00005369159,0.0004752873,0.0001365206,0.00008244732,0.00005646525,0.0002198931,0.00004381768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007005325,"about_ca_system_score_gemma":0.0003655626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002560269,"about_ca_topic_score_gemma":0.0001555297,"domain_scores_codex":[0.9985628,0.00009108982,0.000295639,0.0004091887,0.0003777728,0.0002634742],"domain_scores_gemma":[0.9989932,0.0001012944,0.00009903756,0.0005045196,0.0002704691,0.00003145744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001840332,0.000176622,0.002951134,0.0005462414,0.00007610524,0.0004138011,0.0003021565,4.331236e-8,0.9909456,0.001043708,0.00002308646,0.003337445],"study_design_scores_gemma":[0.001818465,0.0003894799,0.02273703,0.0002321172,0.0001103314,0.0001915033,0.000041395,0.00003708519,0.9733141,0.0008125645,0.0001893852,0.0001265174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952641,0.0009246304,0.002384221,0.0002982829,0.0001160543,0.0004112425,0.000007823466,0.00004067221,0.000552985],"genre_scores_gemma":[0.9961836,0.0000203522,0.0003491644,0.003242877,0.00008396075,0.00005203562,0.000008782408,0.00002401933,0.0000352037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0197859,"threshold_uncertainty_score":0.504846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01682283749919672,"score_gpt":0.3014126413221572,"score_spread":0.2845898038229605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}