{"id":"W3176790120","doi":"10.1128/mbio.00788-21","title":"Identification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects","year":2021,"lang":"en","type":"article","venue":"mBio","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; University of Ottawa","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Biology; Viral evolution; Mutation; Selection (genetic algorithm); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Adaptation (eye); Virology; Genetics; Mutation rate; Spike (software development); Coronavirus disease 2019 (COVID-19); Computational biology; RNA; Gene; Medicine; Disease; Infectious disease (medical specialty); Neuroscience; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001144586,0.0002216435,0.0002116326,0.0002833039,0.000144233,0.0002022227,0.0001149446,0.0003075313,0.0006799731],"category_scores_gemma":[0.000192631,0.00007554507,0.0002669977,0.0001875514,0.0001567133,0.0001037281,0.0002203339,0.0003141725,0.0001747472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001548732,"about_ca_system_score_gemma":0.00009588419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004227625,"about_ca_topic_score_gemma":0.0005984486,"domain_scores_codex":[0.9998993,0.00001605878,0.000009609422,0.00002068851,0.00002992077,0.00002435787],"domain_scores_gemma":[0.9998765,0.00002792399,0.00002824641,0.00002198394,0.00001548458,0.0000298419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00006762438,0.00001828757,0.001175869,0.000004845419,0.000004848489,0.0002712751,0.00001780297,0.00002454407,0.9978676,0.00004380188,0.00001129817,0.0004921402],"study_design_scores_gemma":[0.00002514564,0.0009749254,0.08521026,0.000004668203,0.00004222838,0.01019406,0.000157013,0.002599515,0.8990724,0.0001260958,0.001572038,0.0000215933],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986516,0.00005546815,0.0009108916,0.00001886685,0.00000642765,0.00001083395,0.0001065705,0.00001117298,0.0002281961],"genre_scores_gemma":[0.9985097,0.00003198296,0.0008554089,0.00001891551,0.000004451025,0.000005664618,0.0002540344,0.000009196994,0.0003106576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006799731,"threshold_uncertainty_score":0.002274752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01682283749919672,"score_gpt":0.3014126413221572,"score_spread":0.2845898038229605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}