{"id":"W3176898233","doi":"10.3390/microorganisms9071408","title":"Identification of Resistance Determinants for a Promising Antileishmanial Oxaborole Series","year":2021,"lang":"en","type":"article","venue":"Microorganisms","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Universiteit Antwerpen; Fonds Wetenschappelijk Onderzoek; Wellcome Trust","keywords":"Biology; Cosmid; Amastigote; Gene; Genetics; Cleavage and polyadenylation specificity factor; Computational biology; Leishmania; Polyadenylation; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002857926,0.0001249666,0.0003642687,0.00006706659,0.0001488435,0.00004348601,0.0001024055,0.00006793709,0.00004920168],"category_scores_gemma":[0.0006287013,0.000122444,0.00009489692,0.0002555388,0.00016812,0.0001409328,0.00007541259,0.00008253969,0.00001412904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006684009,"about_ca_system_score_gemma":0.0002392867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003388127,"about_ca_topic_score_gemma":0.00008921038,"domain_scores_codex":[0.9986755,0.00003821008,0.0004340615,0.0003290179,0.0002486518,0.0002745229],"domain_scores_gemma":[0.9986279,0.00005590332,0.0001550137,0.000378282,0.0007226143,0.00006027215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002422291,0.0001245174,0.004334345,0.000555119,0.00005682161,0.00004509998,0.0005687919,1.014981e-7,0.9909483,0.000242455,0.002119421,0.0007628647],"study_design_scores_gemma":[0.0009594206,0.0001044839,0.03022961,0.0001537481,0.0000652415,0.00007036013,0.0005820417,0.000007380011,0.9610701,0.0002789794,0.006376504,0.0001021503],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955046,0.00092623,0.001168726,0.001312455,0.0001395507,0.0005842131,0.00006624147,0.00004320114,0.0002548363],"genre_scores_gemma":[0.9789354,0.0001512746,0.00575274,0.0000681774,0.0001207441,0.00004487472,0.00002247258,0.00004051761,0.01486382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02987816,"threshold_uncertainty_score":0.4993121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01808375743037489,"score_gpt":0.3061416062521857,"score_spread":0.2880578488218108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}