{"id":"W3176922148","doi":"10.1002/art.41901","title":"Phase <scp>IIa</scp> Global Study Evaluating Rituximab for the Treatment of Pediatric Patients With Granulomatosis With Polyangiitis or Microscopic Polyangiitis","year":2021,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Vasculitis and related conditions","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada); SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Versus Arthritis; Action Medical Research","keywords":"Medicine; Tolerability; Rituximab; Granulomatosis with polyangiitis; Body surface area; Internal medicine; Microscopic polyangiitis; Adverse effect; Regimen; Pharmacokinetics; Gastroenterology; Dosing; Vasculitis; Pharmacodynamics; Surgery; Disease; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002111514,0.0008725022,0.0009585493,0.000192769,0.000200032,0.0004628533,0.0003854605,0.000521838,0.001198824],"category_scores_gemma":[0.0008642512,0.0002778789,0.0006839999,0.0003067363,0.0003837102,0.0002774188,0.0002252881,0.001060478,0.00029478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006377356,"about_ca_system_score_gemma":0.001687379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009606082,"about_ca_topic_score_gemma":0.002202147,"domain_scores_codex":[0.9992637,0.0005176244,0.00004160794,0.00005695717,0.00006001127,0.00006012504],"domain_scores_gemma":[0.9990218,0.0001588416,0.0003425712,0.00004388932,0.0001037988,0.0003290306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4176221,0.02427912,0.2646344,0.00295899,0.006923737,0.001235867,0.0004942813,0.003835232,0.06001244,0.0004338943,0.01350184,0.2040681],"study_design_scores_gemma":[0.3515408,0.3024305,0.3184347,0.0002743424,0.00254119,0.002642777,0.0001081689,0.001642318,0.006229165,0.0001096213,0.01401361,0.00003271661],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886213,0.005917915,0.0004986653,0.0005040211,0.00004468943,0.001466166,0.001316453,0.00004667694,0.001584118],"genre_scores_gemma":[0.9862027,0.003668459,0.003069108,0.001317222,0.0001586082,0.001379205,0.003612607,0.00002927275,0.0005628534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002111514,"threshold_uncertainty_score":0.01116687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01562640103870189,"score_gpt":0.3043563299014742,"score_spread":0.2887299288627723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}