{"id":"W3176923618","doi":"10.1136/rmdopen-2021-001660","title":"Hydroxychloroquine in patients with inflammatory and erosive osteoarthritis of the hands: results of the OA-TREAT study—a randomised, double-blind, placebo-controlled, multicentre, investigator-initiated trial","year":2021,"lang":"en","type":"article","venue":"RMD Open","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Bundesministerium für Bildung und Forschung","keywords":"Medicine; Placebo; Osteoarthritis; Adverse effect; Clinical endpoint; Physical therapy; Hydroxychloroquine; Randomized controlled trial; Internal medicine; Disease; Alternative medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005024594,0.0002776936,0.0009988872,0.00007917042,0.0001192341,0.00005200076,0.0002758826,0.0001171213,0.00003021207],"category_scores_gemma":[0.000590021,0.0001527221,0.0001410593,0.0003647367,0.0001984722,0.0001838665,0.0003613762,0.0002111023,0.000002350394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005277017,"about_ca_system_score_gemma":0.0004254595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001691349,"about_ca_topic_score_gemma":0.002502746,"domain_scores_codex":[0.9975109,0.000458622,0.0008475587,0.0004073267,0.0005146007,0.0002609554],"domain_scores_gemma":[0.9980823,0.0002888195,0.0005039763,0.0006684273,0.000298594,0.0001578465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9104155,0.001263883,0.08452952,0.00004638853,0.0001935926,0.00004917658,0.001811179,0.00000622258,0.0006699183,0.00001881485,0.00005196537,0.0009438193],"study_design_scores_gemma":[0.9535797,0.005061871,0.009658104,0.0008647476,0.000558742,0.000006584889,0.0008562825,0.000006253404,0.02919301,0.00001801985,0.00004924443,0.0001474191],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802866,0.0003137121,1.084454e-7,0.0002327494,0.0001896066,0.01754446,0.00006576345,0.00001034248,0.00135665],"genre_scores_gemma":[0.9983547,0.00002345106,0.00002885768,0.0001223302,0.00004018431,0.0005689416,0.00006130831,0.00003009592,0.0007701436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07487141,"threshold_uncertainty_score":0.6227828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02392067448828364,"score_gpt":0.2632701691185669,"score_spread":0.2393494946302832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}