{"id":"W3176948346","doi":"10.1101/2021.06.23.449282","title":"Structure, activity and inhibition of human TMPRSS2, a protease implicated in SARS-CoV-2 activation","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Structural Genomics Consortium; University of Toronto; University of British Columbia","funders":"Office of Science; Genentech; Ontario Genomics; National Institutes of Health; Innovative Medicines Initiative; Wellcome Trust; Office of Research Infrastructure Programs, National Institutes of Health; Genome Canada; Bayer; Pfizer; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Argonne National Laboratory; U.S. Department of Energy","keywords":"Ectodomain; TMPRSS2; Proteases; Serine protease; Protease; Transmembrane protein; Biology; Coronavirus; Enzyme; Viral entry; Biochemistry; Virus; Virology; Chemistry; Viral replication; Receptor; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001112716,0.0002165647,0.000140182,0.00009467544,0.00007666999,0.0001211988,0.0001655236,0.0001986308,0.0004949846],"category_scores_gemma":[0.00009504686,0.00007753966,0.0001812571,0.0001057189,0.0001017284,0.00008342823,0.00004531146,0.0001999971,0.0001675267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002449868,"about_ca_system_score_gemma":0.0001525013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009125638,"about_ca_topic_score_gemma":0.0008990489,"domain_scores_codex":[0.9999317,0.0000127488,0.000006858158,0.00001373626,0.00002344706,0.00001140381],"domain_scores_gemma":[0.9999733,0.000006139783,0.000007734732,0.000002958212,0.000004385061,0.000005475229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003028195,0.00004509285,0.0003697076,0.00002555862,0.00001031314,0.00005682565,0.00001041635,0.000365149,0.9973671,0.00005797805,0.0001185229,0.001270512],"study_design_scores_gemma":[0.00006752471,0.001388206,0.005048374,0.000004540077,0.00002389034,0.0005318889,0.00001385061,0.002844327,0.9869839,0.00003566908,0.003052915,0.00000492926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953305,0.002734133,0.0006399746,0.00007259429,0.00001679133,0.00001597868,0.0005832828,0.00001945426,0.0005871668],"genre_scores_gemma":[0.9958045,0.001030761,0.0008816933,0.00004336194,0.000008526314,0.00001253385,0.001315857,0.000005187489,0.0008975668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009125638,"threshold_uncertainty_score":0.001814485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03612929218791446,"score_gpt":0.3106590437025003,"score_spread":0.2745297515145859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}