{"id":"W3176948346","doi":"10.1101/2021.06.23.449282","title":"Structure, activity and inhibition of human TMPRSS2, a protease implicated in SARS-CoV-2 activation","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Structural Genomics Consortium; University of Toronto; University of British Columbia","funders":"Office of Science; Genentech; Ontario Genomics; National Institutes of Health; Innovative Medicines Initiative; Wellcome Trust; Office of Research Infrastructure Programs, National Institutes of Health; Genome Canada; Bayer; Pfizer; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Argonne National Laboratory; U.S. Department of Energy","keywords":"Ectodomain; TMPRSS2; Proteases; Serine protease; Protease; Transmembrane protein; Biology; Coronavirus; Enzyme; Viral entry; Biochemistry; Virus; Virology; Chemistry; Viral replication; Receptor; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004704292,0.0004674444,0.0008245527,0.0006630769,0.00009035712,0.0001172746,0.0001733532,0.0007029505,0.00000566801],"category_scores_gemma":[0.0004062824,0.0004979564,0.0001246585,0.0009166986,0.0001857934,0.0002306063,0.0004447054,0.001279541,0.000002253383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004721061,"about_ca_system_score_gemma":0.001139782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001038563,"about_ca_topic_score_gemma":0.00004285506,"domain_scores_codex":[0.9971683,0.0002042789,0.0005537801,0.001051701,0.0005595537,0.000462405],"domain_scores_gemma":[0.9977279,0.00005402446,0.0004168604,0.001051295,0.0006763719,0.00007358089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002404033,0.0003613398,0.03164381,0.00165043,0.00009748212,0.00008604073,0.00002547851,3.625674e-7,0.965799,0.00007166013,0.0000123465,0.00001163008],"study_design_scores_gemma":[0.001239794,0.000100707,0.2553091,0.0008798132,0.00005282995,5.908515e-8,0.00000383408,0.0001025498,0.7419132,0.000007983752,0.000092792,0.0002973477],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972809,0.0001780282,0.0001681967,0.0001351101,0.00008160246,0.00192015,0.00009291806,0.0001337212,0.000009351136],"genre_scores_gemma":[0.9977719,0.000009693998,0.0003977924,0.001306426,0.0001439087,0.0002771116,0.000001178541,0.00009171756,2.311932e-7],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2238858,"threshold_uncertainty_score":0.9997472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03612929218791446,"score_gpt":0.3106590437025003,"score_spread":0.2745297515145859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}