{"id":"W3177050132","doi":"10.2337/db21-123-or","title":"123-OR: Deletion of Both Pcsk1 And Pcsk2 in Beta Cells: Lack of Mature Insulin Drives Beta-Cell Expansion and Dysfunction, but Not Severe Diabetes in Mice","year":2021,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Internal medicine; Endocrinology; Proinsulin; Islet; Insulin; Prohormone; Beta cell; Prohormone convertase; Diabetes mellitus; Biology; Chemistry; Medicine; Hormone","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004492161,0.001578719,0.0008418285,0.00100125,0.0004468558,0.001125727,0.0009614565,0.001229232,0.01324359],"category_scores_gemma":[0.0001752018,0.0008428712,0.0009496124,0.0005222965,0.0009961079,0.00076021,0.0006746796,0.002650671,0.004764848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004914285,"about_ca_system_score_gemma":0.000517543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005848957,"about_ca_topic_score_gemma":0.0009252923,"domain_scores_codex":[0.9991851,0.00008354285,0.000108383,0.0001785299,0.0002764653,0.0001679256],"domain_scores_gemma":[0.9994494,0.00003853888,0.0001774071,0.00004570369,0.00003227528,0.0002566178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009967163,0.0002616794,0.0003624177,0.0001363493,0.00004015338,0.0002845006,0.00004102393,0.00009223548,0.9932127,0.0005323429,0.0006595646,0.003380376],"study_design_scores_gemma":[0.0009474074,0.002203834,0.01067377,0.0001061189,0.0002404331,0.003613603,0.0002000394,0.00192408,0.9527584,0.0003139073,0.02696161,0.00005681052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9495994,0.002546938,0.01952457,0.001041712,0.0006867017,0.0006421558,0.009106911,0.002097009,0.01475466],"genre_scores_gemma":[0.8858069,0.00389449,0.01855182,0.001085919,0.0002408047,0.001020628,0.0094544,0.001187393,0.0787576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01324359,"threshold_uncertainty_score":0.04430419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01584846928249801,"score_gpt":0.2349896201242427,"score_spread":0.2191411508417447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}