{"id":"W3177138818","doi":"10.1055/a-1532-8656","title":"Total Synthesis of Methyl 1,5,8-Trimethoxy-1H-isochromene-3-carboxylate and Its Derivatives via Palladium-Catalyzed Annulation of 2-Alkynylbenzaldehydes","year":2021,"lang":"en","type":"article","venue":"Synthesis","topic":"Synthesis and Biological Activity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"Natural Sciences and Engineering Research Council of Canada; TDC Research; Canada Excellence Research Chairs, Government of Canada; Canada Foundation for Innovation","keywords":"Chemistry; Annulation; Sonogashira coupling; Palladium; Catalysis; Carboxylate; Total synthesis; Medicinal chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002227559,0.0003708593,0.0003788872,0.0003266313,0.0001954099,0.0001854875,0.0004253723,0.0002525007,0.002302767],"category_scores_gemma":[0.0001161793,0.0001355796,0.0002753576,0.000289697,0.0001603107,0.0002840155,0.0002951453,0.0004291647,0.001066689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002698988,"about_ca_system_score_gemma":0.0005769905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006388488,"about_ca_topic_score_gemma":0.001274142,"domain_scores_codex":[0.9998661,0.0000172753,0.00000888673,0.0000281931,0.00003686786,0.00004260476],"domain_scores_gemma":[0.9999174,0.000006141396,0.00001172284,0.00001171148,0.00002400742,0.00002912243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007522414,0.00003620691,0.00007563482,0.0001280294,0.00001650623,0.0001325293,0.00005116619,0.0003156745,0.992213,0.0007634087,0.000119613,0.006072959],"study_design_scores_gemma":[0.00002434981,0.000297552,0.001115337,0.000009499506,0.00002863939,0.0002223106,0.00001445566,0.0004802516,0.9909671,0.0001423534,0.006680631,0.00001759426],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9373911,0.004746212,0.03418789,0.000199918,0.0001180133,0.0003144666,0.001427437,0.0004352014,0.02117978],"genre_scores_gemma":[0.9736138,0.002560842,0.01371685,0.00008668653,0.00001933445,0.0001306911,0.0006899005,0.00007437227,0.009107446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002302767,"threshold_uncertainty_score":0.007703543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01549454475787897,"score_gpt":0.2532418099149568,"score_spread":0.2377472651570779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}