{"id":"W3177184192","doi":"10.1096/fasebj.2019.33.1_supplement.817.10","title":"Fluconazole Inhibits Cytochrome P450 1B1 and its Associated Arachidonic Acid Metabolites in the Heart and Protects against Angiotensin II‐induced Cardiac Hypertrophy","year":2019,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Qassim University","keywords":"Fluconazole; Hydroxyeicosatetraenoic acid; Metabolite; Arachidonic acid; Chemistry; Cytochrome P450; Pharmacology; CYP1B1; Endocrinology; Angiotensin II; Internal medicine; Western blot; CYP3A; Metabolism; Biochemistry; Enzyme; Biology; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001103679,0.000395415,0.0004383175,0.000243961,0.0002198775,0.0001669419,0.0002055814,0.0003321635,0.001296281],"category_scores_gemma":[0.0001028248,0.0001376638,0.0003393615,0.0001698554,0.0001753482,0.0001538775,0.0001160837,0.0007734767,0.0002088632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002520579,"about_ca_system_score_gemma":0.0003014199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002757434,"about_ca_topic_score_gemma":0.006381541,"domain_scores_codex":[0.9998981,0.000016304,0.000008082387,0.00001224379,0.00002144784,0.0000437821],"domain_scores_gemma":[0.9999471,0.000006741089,0.00001407835,0.00000602171,0.000009887388,0.00001619684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001208791,0.0004224356,0.0007687491,0.000121679,0.00002809387,0.0001041642,0.00001865404,0.00008986491,0.9902579,0.00005955976,0.0003710174,0.006549168],"study_design_scores_gemma":[0.0004377311,0.008605511,0.05369226,0.00003281252,0.0001268435,0.0004651307,0.0001085418,0.0020486,0.9297295,0.00008098246,0.004653999,0.00001819106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918815,0.005130432,0.0008524997,0.0003515716,0.00007268055,0.00004125355,0.0003547515,0.000108829,0.001206378],"genre_scores_gemma":[0.9939459,0.002402172,0.0005705369,0.0001630648,0.00003227734,0.00003785242,0.0004975341,0.00000836416,0.002342387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002757434,"threshold_uncertainty_score":0.005482733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01192553263533417,"score_gpt":0.2363309153680962,"score_spread":0.2244053827327621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}