{"id":"W3177208116","doi":"10.1096/fasebj.2018.32.1_supplement.533.92","title":"Early growth response protein‐1 (Egr‐1) expression by hydrogen peroxide (H <sub>2</sub> O <sub>2</sub> ) is mediated via c‐Src and PKB‐dependent CREB signaling events in vascular smooth muscle cells (VSMC)","year":2018,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Phosphorylation; CREB; Vascular smooth muscle; Wortmannin; Protein kinase B; Proto-oncogene tyrosine-protein kinase Src; Chemistry; Signal transduction; Cell biology; Gene silencing; Growth factor; PI3K/AKT/mTOR pathway; Reactive oxygen species; Transcription factor; Internal medicine; Endocrinology; Biology; Receptor; Biochemistry; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000144573,0.000767171,0.0003302025,0.0002290105,0.0001548911,0.000291944,0.0001365006,0.0003815775,0.001759586],"category_scores_gemma":[0.00007550402,0.0002539299,0.0004698526,0.0001809589,0.0003357668,0.0002545679,0.0002294218,0.0007303596,0.0004057851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002734259,"about_ca_system_score_gemma":0.0001510363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006335256,"about_ca_topic_score_gemma":0.0009654192,"domain_scores_codex":[0.9998907,0.0000169792,0.000008210998,0.00001806296,0.00002721622,0.00003891114],"domain_scores_gemma":[0.9999342,0.00001349742,0.00002100682,0.00000870552,0.000007114317,0.0000155115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001303118,0.00003982314,0.00008546507,0.00004326857,0.000005092843,0.00005505388,0.00001253666,0.00004300114,0.9989527,0.00002382109,0.00005829662,0.0005504944],"study_design_scores_gemma":[0.00002317871,0.0005443252,0.006647532,0.000005906742,0.00001528208,0.0001798425,0.00004001204,0.0003666669,0.9909275,0.00004428583,0.001200985,0.000004614033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993727,0.002335516,0.001986816,0.0002371484,0.00009064602,0.00004632378,0.0004503851,0.0001169042,0.001009316],"genre_scores_gemma":[0.9900606,0.002913988,0.002213396,0.0002016113,0.00003291646,0.00008797922,0.0006190878,0.00002386054,0.003846487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001759586,"threshold_uncertainty_score":0.005886436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008149876631107474,"score_gpt":0.2162659682701245,"score_spread":0.2081160916390171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}