{"id":"W3177209562","doi":"10.1186/s12931-021-01767-z","title":"Impact of baseline clinical asthma characteristics on the response to mepolizumab: a post hoc meta-analysis of two Phase III trials","year":2021,"lang":"en","type":"review","venue":"Respiratory Research","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital du Sacré-Cœur de Montréal","funders":"GlaxoSmithKline","keywords":"Medicine; Mepolizumab; Asthma; Placebo; Internal medicine; Post-hoc analysis; Physical therapy; Eosinophil; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02459253,0.004924793,0.0164961,0.001957895,0.0006066736,0.00402337,0.002196015,0.002514196,0.0041612],"category_scores_gemma":[0.02460127,0.001883835,0.06129652,0.002428448,0.0009781842,0.001710213,0.001531491,0.00310756,0.0005398531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001761366,"about_ca_system_score_gemma":0.001423209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00299071,"about_ca_topic_score_gemma":0.004111077,"domain_scores_codex":[0.9828179,0.01241611,0.001563336,0.001834726,0.0008702986,0.0004976898],"domain_scores_gemma":[0.9794009,0.01496313,0.002488896,0.001783363,0.0009147965,0.0004489475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.02922915,0.00004402556,0.002856539,0.009883106,0.9549256,0.00006224885,0.00002156059,0.0007495024,0.0004211699,0.00004327548,0.0002816984,0.001482215],"study_design_scores_gemma":[0.007368418,0.0008407172,0.003683302,0.0003919642,0.9863594,0.00003945138,0.00001745831,0.0005043493,0.0001850909,0.0001538326,0.0004356049,0.00002040873],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2830548,0.6859654,0.01215125,0.001574924,0.002823448,0.003467324,0.007350103,0.0006114963,0.003001168],"genre_scores_gemma":[0.9591773,0.02927906,0.003956995,0.001239685,0.0004117809,0.002183375,0.002249068,0.0001801274,0.001322653],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02459253,"threshold_uncertainty_score":0.1300593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.6275910926122141,"score_gpt":0.6361010728883633,"score_spread":0.008509980276149132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}