{"id":"W3177253938","doi":"10.1038/s41557-021-00718-x","title":"Integrating programmable DNAzymes with electrical readout for rapid and culture-free bacterial detection using a handheld platform","year":2021,"lang":"en","type":"article","venue":"Nature Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":127,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Government of Canada","keywords":"Deoxyribozyme; Chemistry; Mobile device; Nanotechnology; Computer hardware; Detection limit; Computer science; Operating system; Chromatography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008502258,0.0001896773,0.000182166,0.00001435257,0.0001396696,0.00007367195,0.00008866059,0.0005718606,0.000001513093],"category_scores_gemma":[0.0002910582,0.0001439262,0.00008414851,0.0001443307,0.0000652306,0.00000993061,0.00006554449,0.000304702,3.212012e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002926191,"about_ca_system_score_gemma":0.00007827627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002608215,"about_ca_topic_score_gemma":0.00002513986,"domain_scores_codex":[0.9990762,0.0000098235,0.0001460656,0.0004309963,0.0001043123,0.0002325893],"domain_scores_gemma":[0.9993236,0.00001164207,0.0000969426,0.0002705396,0.0002342871,0.0000629772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002679371,0.00002863696,0.00005695321,0.0000479427,0.00006896923,0.00000472664,0.000009123386,3.695368e-7,0.9902698,0.000005086042,0.000157883,0.00908255],"study_design_scores_gemma":[0.0006023567,0.0001592933,0.000007528524,0.00004580684,0.00007412914,0.0002137563,0.00005434749,0.0001729239,0.9794979,0.00009635623,0.01886183,0.000213754],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905658,0.001708617,0.007024278,0.00007574981,0.00004382216,0.0001750258,0.00003259375,0.00006142442,0.0003126239],"genre_scores_gemma":[0.9440503,0.0001284625,0.05445301,0.0000839251,0.0004715558,0.00001622558,0.0003130753,0.00002250239,0.0004609461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04742873,"threshold_uncertainty_score":0.5869141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006505209683527561,"score_gpt":0.2577444839116712,"score_spread":0.2512392742281436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}