{"id":"W3177289604","doi":"10.1038/s41589-021-00813-7","title":"Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth","year":2021,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"National Cancer Institute; Breast Cancer Research Foundation","keywords":"mTORC1; Chemistry; Cell biology; Computational biology; Biochemistry; Cancer research; Biology; PI3K/AKT/mTOR pathway; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000141797,0.0005994784,0.0003658088,0.0006438007,0.0002818145,0.0003753615,0.0003211936,0.0002856857,0.002824177],"category_scores_gemma":[0.0001554901,0.0002523228,0.0002813589,0.0005355283,0.0002745214,0.0002347183,0.0002342365,0.001077532,0.0007373913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007338211,"about_ca_system_score_gemma":0.0005579332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008113497,"about_ca_topic_score_gemma":0.003073765,"domain_scores_codex":[0.9998698,0.0000108558,0.000007525637,0.00001882096,0.00003843828,0.00005456256],"domain_scores_gemma":[0.9999352,0.00001252532,0.00001689848,0.000008180802,0.000008342894,0.00001889373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001013265,0.0004179007,0.0004792969,0.0002006642,0.00005650274,0.0001172627,0.00002214334,0.001336332,0.971673,0.002871083,0.003058316,0.01875426],"study_design_scores_gemma":[0.0001173895,0.0004593738,0.001610625,0.000006552413,0.00003780569,0.0001973651,0.00002665745,0.001144816,0.9853957,0.0003357745,0.01065831,0.000009502307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9468171,0.01460743,0.01057351,0.001574927,0.0005485691,0.0001712874,0.003070659,0.001312464,0.02132413],"genre_scores_gemma":[0.9802582,0.006744123,0.003442543,0.0002898506,0.00006443045,0.000131431,0.001577629,0.0000842523,0.007407669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002824177,"threshold_uncertainty_score":0.009447873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003498438430068164,"score_gpt":0.2485479323060553,"score_spread":0.2450494938759871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}