{"id":"W3177289604","doi":"10.1038/s41589-021-00813-7","title":"Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth","year":2021,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"National Cancer Institute; Breast Cancer Research Foundation","keywords":"mTORC1; Chemistry; Cell biology; Computational biology; Biochemistry; Cancer research; Biology; PI3K/AKT/mTOR pathway; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008406162,0.0001820337,0.0002642598,0.00002946563,0.00002737138,0.000006638225,0.0001671967,0.0007389568,0.00002472436],"category_scores_gemma":[0.0005820613,0.0001650726,0.00008805305,0.0001444113,0.0002448281,0.000003205485,0.000211458,0.0004648964,0.000001202462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002500668,"about_ca_system_score_gemma":0.0001130938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007136925,"about_ca_topic_score_gemma":0.00000249433,"domain_scores_codex":[0.9988532,0.00007345626,0.00020079,0.000528099,0.00007861386,0.0002658144],"domain_scores_gemma":[0.9992445,0.00006829562,0.0001020135,0.000227554,0.000271755,0.00008595832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001353595,0.00004471384,0.004379701,0.00003800514,0.00008723898,0.000004737765,0.0000222502,4.034462e-7,0.9924777,0.0002843769,0.002251799,0.0002737053],"study_design_scores_gemma":[0.0004684339,0.0001268688,0.0003772963,0.00002123473,0.00001833936,0.00004049639,0.00001777804,0.000002097825,0.9903671,0.0006449698,0.007733153,0.0001823041],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938567,0.00469284,0.00003999093,0.0002100812,0.0002694213,0.00008001798,0.00007347464,0.00001350463,0.0007639331],"genre_scores_gemma":[0.9981392,0.0001017674,0.000500913,0.0005451524,0.0004389784,0.00001387252,0.0001876803,0.00002058412,0.00005182028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005481353,"threshold_uncertainty_score":0.6731467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003498438430068164,"score_gpt":0.2485479323060553,"score_spread":0.2450494938759871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}