{"id":"W3177309704","doi":"10.1158/0008-5472.can-20-3761","title":"<i>TET2</i> and <i>DNMT3A</i> Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"PARP1; DNA repair; Biology; Cancer research; Synthetic lethality; Mutation; Homologous recombination; DNA damage; PARP inhibitor; DNA methylation; Molecular biology; Poly ADP ribose polymerase; Genetics; DNA; Gene; Polymerase; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001289872,0.0002900618,0.0002647268,0.0001936612,0.0001215513,0.0003216907,0.0001831712,0.0002709624,0.001177451],"category_scores_gemma":[0.0001259715,0.0001434527,0.000263692,0.000168028,0.0001506412,0.0001495877,0.0002169961,0.0005675588,0.000328961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000265599,"about_ca_system_score_gemma":0.0001194028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006642561,"about_ca_topic_score_gemma":0.0007075496,"domain_scores_codex":[0.999763,0.00003126852,0.00003652984,0.00004131462,0.00007555319,0.00005226753],"domain_scores_gemma":[0.9998769,0.00001626694,0.00003479446,0.00002306809,0.00001320288,0.00003577151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008307789,0.00001756065,0.0002361664,0.000007879453,0.000005759538,0.00001499243,0.000006014717,0.00003547745,0.9989212,0.0000518349,0.000030605,0.000589421],"study_design_scores_gemma":[0.00001288658,0.0003605264,0.009561248,0.000003013293,0.00001715452,0.0003169288,0.00002223685,0.0005969804,0.9875572,0.00002848148,0.001519803,0.000003484714],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961241,0.0007665999,0.0009376795,0.00005786671,0.00001850646,0.00002122116,0.0006913534,0.00007373754,0.001308994],"genre_scores_gemma":[0.9966344,0.0003245699,0.0006027131,0.00004641662,0.000005428519,0.00003187716,0.001053258,0.00002067566,0.001280642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001177451,"threshold_uncertainty_score":0.003938973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02201513646187164,"score_gpt":0.3333466836415265,"score_spread":0.3113315471796548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}