{"id":"W3177309704","doi":"10.1158/0008-5472.can-20-3761","title":"<i>TET2</i> and <i>DNMT3A</i> Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"PARP1; DNA repair; Biology; Cancer research; Synthetic lethality; Mutation; Homologous recombination; DNA damage; PARP inhibitor; DNA methylation; Molecular biology; Poly ADP ribose polymerase; Genetics; DNA; Gene; Polymerase; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000550024,0.00008710417,0.0001189953,0.00005103805,0.0001070665,0.00001830422,0.00002935439,0.0000846027,0.000004816668],"category_scores_gemma":[0.0002229548,0.00008677333,0.00003817724,0.0001697541,0.00008727948,0.000002716069,0.0001811895,0.0001081247,0.000002132152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004055502,"about_ca_system_score_gemma":0.0001779177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001332961,"about_ca_topic_score_gemma":0.0002152341,"domain_scores_codex":[0.9988165,0.0002697381,0.0001226105,0.0003578396,0.0002280238,0.0002052622],"domain_scores_gemma":[0.9992222,0.0001391245,0.00002605639,0.0002282557,0.0002403528,0.0001440477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004707688,0.00002203231,0.002492707,0.00007768974,0.00002366188,0.00001521053,0.0001096323,0.0001567178,0.9901361,0.00001864946,0.000922646,0.00597791],"study_design_scores_gemma":[0.0002468871,0.0002242747,0.005160369,0.00004984788,0.000009440264,0.000001164736,0.00004868437,0.00003507849,0.9850048,0.00005814936,0.009070738,0.00009056793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958092,0.003187046,0.0001071275,0.0002357815,0.0001159161,0.0002226206,0.00003455195,0.000005393643,0.0002823672],"genre_scores_gemma":[0.9966182,0.002449076,0.0001960499,0.0001002048,0.000140932,0.00003808479,0.00002430349,0.00001349086,0.0004196951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008148092,"threshold_uncertainty_score":0.3538513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02201513646187164,"score_gpt":0.3333466836415265,"score_spread":0.3113315471796548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}