{"id":"W3177322658","doi":"10.1186/s13072-021-00404-9","title":"Contribution of genetic and epigenetic changes to escape from X-chromosome inactivation","year":2021,"lang":"en","type":"article","venue":"Epigenetics & Chromatin","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Genome British Columbia","keywords":"X-inactivation; Biology; Epigenetics; Genetics; DNA methylation; Chromatin; Gene; Histone; X chromosome; Heterochromatin; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001038752,0.0004743273,0.0004477362,0.0005205599,0.0003116083,0.001046904,0.0003258969,0.0004855284,0.001313778],"category_scores_gemma":[0.00309979,0.0001475098,0.0006043107,0.0004488197,0.0003712704,0.0003734184,0.0006030497,0.0008421142,0.0003206524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004874845,"about_ca_system_score_gemma":0.000326043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002805754,"about_ca_topic_score_gemma":0.003027295,"domain_scores_codex":[0.9995354,0.0000728317,0.00003264658,0.0002222009,0.00009087879,0.00004603599],"domain_scores_gemma":[0.9986633,0.0007901285,0.0002224973,0.0001328832,0.0001193399,0.00007188712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009281115,0.0001465453,0.8364281,0.0002998279,0.0007159996,0.000272681,0.0002200221,0.04609023,0.04595029,0.0005144203,0.0007303881,0.06770336],"study_design_scores_gemma":[0.00003814513,0.0003628337,0.7402714,0.00008033386,0.0004479772,0.0007835256,0.0001963883,0.2288432,0.02345442,0.002516161,0.002944422,0.00006116836],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913113,0.0008790779,0.005671255,0.0001207477,0.00001602028,0.00001670996,0.0009503902,0.0002116326,0.0008228339],"genre_scores_gemma":[0.9960491,0.0001745172,0.001655475,0.00006320533,0.00001164762,0.00001240889,0.001596781,0.00003655087,0.0004003961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002805754,"threshold_uncertainty_score":0.005578876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009651522043247995,"score_gpt":0.25026751187409,"score_spread":0.240615989830842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}