{"id":"W3177333517","doi":"10.1016/j.neurobiolaging.2021.06.014","title":"Unique regional patterns of amyloid burden predict progression to prodromal and clinical stages of Alzheimer's disease","year":2021,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Deutsche Forschungsgemeinschaft; European Federation of Pharmaceutical Industries and Associations; Alzheimer Forschung Initiative; Northern California Institute for Research and Education; F. Hoffmann-La Roche; University of Southern California; Pfizer; BioClinica; Biogen; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; European Commission; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Alzheimer's Association","keywords":"Precuneus; Biomarker; Dementia; Disease; Internal medicine; Amyloid (mycology); Medicine; Oncology; Alzheimer's disease; Psychology; Pathology; Neuroscience; Cognition; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003708908,0.0003233317,0.0002135953,0.0006875074,0.0001619593,0.0003331841,0.000159868,0.0002598746,0.0007126246],"category_scores_gemma":[0.0009252817,0.0001464964,0.0001159401,0.0002125397,0.0002093237,0.0002538181,0.0002538387,0.0002224914,0.0001346226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001217664,"about_ca_system_score_gemma":0.000148305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002001174,"about_ca_topic_score_gemma":0.004571475,"domain_scores_codex":[0.9999259,0.00001665751,0.000009350241,0.00002065349,0.00001427565,0.00001321639],"domain_scores_gemma":[0.9995871,0.00006289914,0.0001818312,0.0000325636,0.00005157971,0.00008400829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009936944,0.00006950207,0.982761,0.00001777056,0.00005212141,0.0002012855,0.0001877084,0.0001619514,0.008479865,0.00004486744,0.00007737767,0.006952885],"study_design_scores_gemma":[0.000005486721,0.0000912162,0.999135,0.000002038532,0.000008599574,0.0002428737,0.00004818827,0.000136021,0.0002508181,0.00004134383,0.00003707797,0.000001433944],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995018,0.0001480997,0.0000657302,0.000005954053,0.000001276697,0.000004354762,0.0000372944,0.000002070616,0.0002333394],"genre_scores_gemma":[0.9995911,0.00005992477,0.00013617,0.000003874219,0.000002699094,0.000002731441,0.00006209537,7.809069e-7,0.0001406473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002001174,"threshold_uncertainty_score":0.003979027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03575015672714092,"score_gpt":0.3765481374903841,"score_spread":0.3407979807632432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}