{"id":"W3177359439","doi":"10.1002/hon.50_2880","title":"UNFAVORABLE GENETICS IMPACT MRD RESPONSE TO VENETOCLAX+RITUXIMAB RETREATMENT IN RELAPSED OR REFRACTORY CHRONIC LYMPHOCYTIC LEUKEMIA (R/R CLL): PHASE 3 MURANO SUBSTUDY","year":2021,"lang":"en","type":"article","venue":"Hematological Oncology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Bendamustine; Venetoclax; Rituximab; Internal medicine; Chronic lymphocytic leukemia; Oncology; Gastroenterology; Minimal residual disease; clone (Java method); Refractory (planetary science); Progression-free survival; Leukemia; Lymphoma; Chemotherapy; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001510491,0.0004559789,0.0006511643,0.000259943,0.0003733851,0.0006785412,0.0003678348,0.0004692978,0.002353449],"category_scores_gemma":[0.001166686,0.0002603567,0.0007727749,0.0003329063,0.0002957004,0.0003218128,0.0003601931,0.0006210429,0.0003511225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005044009,"about_ca_system_score_gemma":0.0004032651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002315777,"about_ca_topic_score_gemma":0.00788861,"domain_scores_codex":[0.9996105,0.0002258594,0.00002442172,0.0000528903,0.00003035422,0.00005603211],"domain_scores_gemma":[0.9994676,0.0001572047,0.0001833265,0.00006418583,0.00002970569,0.00009803228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1367486,0.003030115,0.7052886,0.001266089,0.005122234,0.0003300126,0.0005843393,0.0008941708,0.01735343,0.0003605979,0.01058801,0.1184338],"study_design_scores_gemma":[0.02076993,0.02419934,0.9383063,0.0002382684,0.005118744,0.001019505,0.0001492962,0.0007712229,0.001394839,0.0004012412,0.007594817,0.00003634721],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932549,0.003989242,0.00009433535,0.0001742556,0.00003147489,0.0001565588,0.001119778,0.0000170274,0.001162424],"genre_scores_gemma":[0.9951978,0.001034807,0.0002801664,0.0004369876,0.0001311455,0.0002477797,0.00204008,0.000008695467,0.0006224588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002353449,"threshold_uncertainty_score":0.007988334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05772649493114061,"score_gpt":0.4269626584566331,"score_spread":0.3692361635254924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}