{"id":"W3177376878","doi":"10.3390/cancers13123079","title":"Targeting the Ubiquitin-Proteasome System for Cancer Therapeutics by Small-Molecule Inhibitors","year":2021,"lang":"en","type":"review","venue":"Cancers","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research; University of Guelph","funders":"Canadian Institutes of Health Research","keywords":"Proteasome; Ubiquitin; Proteolysis; Small molecule; Protein degradation; Regulator; Cancer; Computational biology; Biology; Cancer research; Chemistry; Cell biology; Biochemistry; Enzyme; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004197079,0.001003234,0.001166536,0.0020417,0.0002400976,0.0007757246,0.0008830716,0.0009700924,0.004456109],"category_scores_gemma":[0.0004534843,0.0002906584,0.0005700719,0.001626715,0.0002946794,0.001012275,0.000587606,0.002191474,0.003212438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006179803,"about_ca_system_score_gemma":0.0005724868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000535188,"about_ca_topic_score_gemma":0.001335991,"domain_scores_codex":[0.9998243,0.00002326853,0.0000184277,0.00003005792,0.00008098143,0.00002301037],"domain_scores_gemma":[0.9998468,0.00006440669,0.00002239966,0.000005720579,0.00004357322,0.00001696234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001055675,0.000163301,0.0001087215,0.01360064,0.0001110661,0.0002688817,0.00004754692,0.0007458495,0.00748178,0.00513679,0.04425501,0.9279748],"study_design_scores_gemma":[0.00002345296,0.0001250626,0.0002955649,0.001098483,0.00006763157,0.000685855,0.00001367663,0.0001323008,0.001140526,0.0009993474,0.9954054,0.00001270178],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002777101,0.9968767,0.0003561935,0.0002137479,0.0002706196,0.00001336397,0.00004499312,0.00002625054,0.001920427],"genre_scores_gemma":[0.00106961,0.9968572,0.0003357113,0.0002054675,0.0001224445,0.00001668313,0.00007316039,0.000003326629,0.001316439],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004456109,"threshold_uncertainty_score":0.01490712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03425199621979357,"score_gpt":0.3110465156559508,"score_spread":0.2767945194361572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}