{"id":"W3177377376","doi":"10.3390/molecules26133975","title":"Chemical Modulation of the 1-(Piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazole-2-one Scaffold as a Novel NLRP3 Inhibitor","year":2021,"lang":"en","type":"article","venue":"Molecules","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Università degli Studi di Torino; Compagnia di San Paolo; Fondazione CRT","keywords":"Pharmacophore; Imidazole; Chemistry; Inflammasome; Pyroptosis; In vitro; Benzofuran; Stereochemistry; Combinatorial chemistry; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001012826,0.0003495275,0.0002732898,0.0001283496,0.0001116683,0.0001874502,0.0003039388,0.0001901555,0.001602785],"category_scores_gemma":[0.00006600712,0.0001159197,0.0001843089,0.0001816125,0.0001466163,0.0001849582,0.0001491314,0.0003140467,0.0004858021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000229536,"about_ca_system_score_gemma":0.0001836087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002898003,"about_ca_topic_score_gemma":0.0006049423,"domain_scores_codex":[0.9999447,0.00001100738,0.000003006557,0.00001187516,0.00001206778,0.00001736921],"domain_scores_gemma":[0.9999764,0.000002948107,0.000009249658,0.000002124268,0.000003196638,0.000005960772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002864582,0.0002344528,0.000179253,0.0002493166,0.00001495857,0.0001977313,0.00003144879,0.003589845,0.9876103,0.0008883344,0.0001949411,0.006523059],"study_design_scores_gemma":[0.000482743,0.00424633,0.002529068,0.00002710073,0.00008022096,0.000553935,0.00003652162,0.01144416,0.9647232,0.0002884163,0.01554933,0.00003882156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9765214,0.00551839,0.01117404,0.0002760778,0.00008168631,0.0002144187,0.0004464258,0.0002231262,0.00554442],"genre_scores_gemma":[0.9870282,0.002520312,0.007992256,0.0000933906,0.00001650803,0.00008210218,0.0002475536,0.00001676699,0.002002802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001602785,"threshold_uncertainty_score":0.005361915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007502319799247079,"score_gpt":0.2131620496328148,"score_spread":0.2056597298335677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}