{"id":"W3177377376","doi":"10.3390/molecules26133975","title":"Chemical Modulation of the 1-(Piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazole-2-one Scaffold as a Novel NLRP3 Inhibitor","year":2021,"lang":"en","type":"article","venue":"Molecules","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Università degli Studi di Torino; Compagnia di San Paolo; Fondazione CRT","keywords":"Pharmacophore; Imidazole; Chemistry; Inflammasome; Pyroptosis; In vitro; Benzofuran; Stereochemistry; Combinatorial chemistry; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008867618,0.0001939956,0.00019158,0.00002961966,0.00008729324,0.00003047927,0.0002742974,0.0002079736,0.00004993414],"category_scores_gemma":[0.0001990959,0.0001730568,0.0002311114,0.0001896822,0.0001318612,0.000006894858,0.000294676,0.0001059851,0.00001444803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001509307,"about_ca_system_score_gemma":0.0001418999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001948633,"about_ca_topic_score_gemma":0.000010636,"domain_scores_codex":[0.9987566,0.00004615924,0.0003118171,0.0003620145,0.000258475,0.0002648795],"domain_scores_gemma":[0.9990713,0.00001062841,0.0001174307,0.0005755819,0.0001749387,0.00005010969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005472249,0.0001600171,0.0003884756,0.00002729775,0.00006950506,0.000002029115,0.00007859623,0.0002192595,0.9973948,0.0004715758,0.000454965,0.0006787365],"study_design_scores_gemma":[0.0006351161,0.00004507102,0.001874709,0.00004601794,0.00002982824,0.00001815598,0.0001301367,0.0001910194,0.9919842,0.0001167485,0.004714927,0.00021406],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950295,0.0007870069,0.0004588423,0.0005940186,0.0001781329,0.000156992,0.00002154168,0.00001312398,0.002760809],"genre_scores_gemma":[0.9979971,0.0000594871,0.0005884056,0.0004837458,0.0001460317,0.00001955528,0.00014653,0.00003392763,0.0005251958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00541061,"threshold_uncertainty_score":0.705705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007502319799247079,"score_gpt":0.2131620496328148,"score_spread":0.2056597298335677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}