{"id":"W3177448734","doi":"10.1101/2021.06.23.449327","title":"Regulation of GTPase function by autophosphorylation","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Science Foundation; National Institutes of Health; Cancer Research UK; Princess Margaret Cancer Foundation; Canadian Cancer Society Research Institute; American Cancer Society","keywords":"Autophosphorylation; GTPase; Effector; Guanine nucleotide exchange factor; Phosphorylation; Allosteric regulation; Cell biology; Chemistry; Active site; Biology; Biochemistry; Protein kinase A; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009278193,0.0001830118,0.00009477137,0.0001327214,0.000102641,0.0003348658,0.0001694148,0.000111676,0.0009560075],"category_scores_gemma":[0.00009443099,0.00006517667,0.0001055388,0.00007606076,0.0002345009,0.0001316279,0.0001742437,0.0003234297,0.0002193063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002192913,"about_ca_system_score_gemma":0.0000983328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002287859,"about_ca_topic_score_gemma":0.0002283187,"domain_scores_codex":[0.9999369,0.000008986292,0.000003694035,0.00002004865,0.00001845718,0.00001190242],"domain_scores_gemma":[0.9999496,0.00001187804,0.00001046313,0.00001360357,0.000004996558,0.000009454026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000414886,0.00001112813,0.0003826505,0.00001149011,0.00000316466,0.00004509724,0.00001041218,0.0002351731,0.9964394,0.000687543,0.00004046479,0.002091925],"study_design_scores_gemma":[0.0000125788,0.00005525074,0.005132305,0.000003811331,0.000006355469,0.0003265832,0.00002257205,0.00549485,0.9856024,0.0009895697,0.002347225,0.00000655964],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994419,0.0006636034,0.002609938,0.00007309233,0.00001341695,0.000004074772,0.00007572444,0.00008628322,0.00205501],"genre_scores_gemma":[0.9986682,0.0001585745,0.0005753057,0.00001200332,0.000003376888,0.000002667881,0.00005113623,0.00001137364,0.0005173445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009560075,"threshold_uncertainty_score":0.003198147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007470367223243703,"score_gpt":0.203528188733029,"score_spread":0.1960578215097853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}