{"id":"W3177448734","doi":"10.1101/2021.06.23.449327","title":"Regulation of GTPase function by autophosphorylation","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Science Foundation; National Institutes of Health; Cancer Research UK; Princess Margaret Cancer Foundation; Canadian Cancer Society Research Institute; American Cancer Society","keywords":"Autophosphorylation; GTPase; Effector; Guanine nucleotide exchange factor; Phosphorylation; Allosteric regulation; Cell biology; Chemistry; Active site; Biology; Biochemistry; Protein kinase A; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003842943,0.0003400781,0.0003262354,0.0001083708,0.00009201925,0.00007665392,0.0001829738,0.0006685939,0.00007627666],"category_scores_gemma":[0.0001426071,0.0004088054,0.0001854571,0.0002347092,0.00007572788,0.00001307322,0.0002368627,0.0002429784,0.000005590115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007019703,"about_ca_system_score_gemma":0.0003840349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002630031,"about_ca_topic_score_gemma":0.000001382005,"domain_scores_codex":[0.9980568,0.0001340703,0.0005047944,0.0007447613,0.0003106528,0.0002488758],"domain_scores_gemma":[0.9978592,0.000008756274,0.0005204335,0.0008983815,0.000585205,0.0001280371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006544912,0.00008520991,0.0007642093,0.0001848475,0.00009497844,0.000002007524,0.000002354551,0.000761856,0.9973398,0.000131041,0.0005583006,0.000009957757],"study_design_scores_gemma":[0.0003886636,0.00006989751,0.02851748,0.000177419,0.00008253301,1.076063e-8,0.000002044179,0.0009226477,0.964233,0.000002773391,0.005204284,0.0003992792],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9543916,0.004863953,0.03953959,0.00005959433,0.0004787685,0.0004561946,0.0001261508,0.00007347037,0.00001070484],"genre_scores_gemma":[0.9965806,0.0001860613,0.002646526,0.00009220079,0.0002956786,0.00007897922,0.00002690428,0.00007306021,0.00001998582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04218903,"threshold_uncertainty_score":0.9998364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007470367223243703,"score_gpt":0.203528188733029,"score_spread":0.1960578215097853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}