{"id":"W3177453907","doi":"10.1096/fasebj.25.1_supplement.1000.4","title":"HMGB1/TLR4 axis contributes to A/R‐induced cardiomyocyte apoptosis through potentiating TNFα/JNK pathway","year":2011,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Lawson Health Research Institute","funders":"","keywords":"Apoptosis; Myocyte; Tumor necrosis factor alpha; Western blot; HMGB1; Chemistry; Cell biology; TLR4; Programmed cell death; Molecular biology; Signal transduction; Biology; Endocrinology; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002968835,0.0005345524,0.0003769371,0.0002832802,0.0002242187,0.0003037867,0.0001826269,0.0003252932,0.00208117],"category_scores_gemma":[0.000112016,0.0001619113,0.0006048875,0.00009601832,0.0002696069,0.000263156,0.0003356113,0.0007209198,0.0005003261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002352657,"about_ca_system_score_gemma":0.0002648955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000301484,"about_ca_topic_score_gemma":0.0004391142,"domain_scores_codex":[0.9997677,0.00005509227,0.0000281402,0.0000372157,0.00005114559,0.0000606981],"domain_scores_gemma":[0.9998187,0.00001375214,0.00007003522,0.00001595905,0.00002700194,0.0000544677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005539297,0.00004945002,0.001132577,0.0001634037,0.00001956795,0.0002590129,0.00001940253,0.00004416308,0.9963968,0.00007825223,0.00004805759,0.001235294],"study_design_scores_gemma":[0.0001037362,0.001959673,0.03642413,0.00005549478,0.0001554205,0.001801612,0.0002271641,0.001163775,0.9541207,0.0002632655,0.003709205,0.00001590724],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981522,0.01013893,0.005173645,0.000369816,0.0001092159,0.00007460283,0.0004417231,0.00009773512,0.002072407],"genre_scores_gemma":[0.9903694,0.003551204,0.002458998,0.0001568085,0.00006104246,0.00006567901,0.0003822465,0.00001157165,0.002942975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00208117,"threshold_uncertainty_score":0.00696218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03521909727302568,"score_gpt":0.2424938241698431,"score_spread":0.2072747268968175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}