{"id":"W3177526206","doi":"10.1101/2021.07.02.450963","title":"Pharmacokinetics and Central Accumulation of Delta-9-Tetrahydrocannabinol (THC) and its Bioactive Metabolites Are Influenced by Route of Administration and Sex","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; University of Calgary","funders":"Canadian Institutes of Health Research; Mathison Centre for Mental Health Research and Education; Branch Out Neurological Foundation","keywords":"Inhalation; Pharmacokinetics; Metabolite; Pharmacology; Cannabis; Inhalation exposure; Toxicokinetics; Hypothermia; Route of administration; Tetrahydrocannabinol; Delta-9-tetrahydrocannabinol; Chemistry; Cannabinoid; Anesthesia; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007108004,0.0001534326,0.0001466065,0.0001885371,0.0001016147,0.0002285374,0.00007073269,0.0001372694,0.001865841],"category_scores_gemma":[0.000215858,0.0001678389,0.0001623252,0.0001124976,0.0002032536,0.0001469053,0.00008635657,0.0002946954,0.0004187957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001773967,"about_ca_system_score_gemma":0.0001884933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001624736,"about_ca_topic_score_gemma":0.002739377,"domain_scores_codex":[0.9999232,0.000008516944,0.000003598482,0.00002231596,0.00002686353,0.00001558253],"domain_scores_gemma":[0.9998233,0.00002605982,0.00006750711,0.00001926815,0.00003088049,0.0000331268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004444619,0.0003030367,0.06535922,0.00006887178,0.000100554,0.0002365571,0.0001208271,0.0001389271,0.9017715,0.00009248428,0.0003977622,0.02696579],"study_design_scores_gemma":[0.00003897535,0.003286891,0.7704834,0.00001409647,0.00008702157,0.001035492,0.0001857466,0.001099694,0.221082,0.0001268276,0.002538693,0.00002114015],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968637,0.0009600508,0.0007401045,0.00003830817,0.00001456358,0.00002031929,0.0005517555,0.00002352112,0.0007875971],"genre_scores_gemma":[0.9944958,0.0008668439,0.0007359328,0.00005219212,0.000008255896,0.00002974725,0.0004430047,0.00002087843,0.003347345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001865841,"threshold_uncertainty_score":0.006241858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02551190933299527,"score_gpt":0.2992510151262992,"score_spread":0.273739105793304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}