{"id":"W3177568365","doi":"","title":"Safe and immune-tolerant 'designer' RPE cells towards the treatment of age-related macular degeneration","year":2021,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; University of Toronto; Lunenfeld-Tanenbaum Research Institute","funders":"","keywords":"Macular degeneration; Medicine; Degeneration (medical); Ophthalmology; Immune system; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002961168,0.0001631924,0.0001797434,0.00004104733,0.0002519964,0.00003308255,0.0001748613,0.00009992607,0.00003953903],"category_scores_gemma":[0.000090464,0.000114868,0.00005948676,0.0003414302,0.002517579,0.00001057022,0.0000941739,0.00004932835,0.000004623821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002504681,"about_ca_system_score_gemma":0.0004411096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000064981,"about_ca_topic_score_gemma":0.000004963966,"domain_scores_codex":[0.9987093,0.0001809984,0.0002503851,0.0004322474,0.0001842461,0.0002427816],"domain_scores_gemma":[0.9994123,0.00002189968,0.000111334,0.0001943479,0.0001660913,0.00009404912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002118358,0.00008974301,0.002373113,0.000004397658,0.0000319826,0.00005682815,0.0006246314,0.00005777098,0.9956894,0.0001294235,0.00001372691,0.0009077826],"study_design_scores_gemma":[0.0003429664,0.0007300234,0.03089443,0.000008787855,0.00001885226,0.00008984804,0.0002365831,0.0001417886,0.9661359,0.0009516351,0.0003157316,0.0001335047],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960172,0.001653193,0.00001412009,0.0003037337,0.0001509737,0.0001841423,0.000004037268,0.000003965092,0.001668644],"genre_scores_gemma":[0.9975631,0.0002170953,0.001280499,0.00008493682,0.00002072321,0.00002224195,0.0000430148,0.000007707902,0.0007606813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02955357,"threshold_uncertainty_score":0.9276125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02700555963824746,"score_gpt":0.2953241612634984,"score_spread":0.268318601625251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}