{"id":"W3177568365","doi":"","title":"Safe and immune-tolerant 'designer' RPE cells towards the treatment of age-related macular degeneration","year":2021,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; University of Toronto; Lunenfeld-Tanenbaum Research Institute","funders":"","keywords":"Macular degeneration; Medicine; Degeneration (medical); Ophthalmology; Immune system; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003116181,0.000197475,0.0003106354,0.0001894029,0.00009622483,0.0004398243,0.0002373814,0.0004485355,0.001121018],"category_scores_gemma":[0.0002028072,0.00009751127,0.0002022141,0.00009040565,0.00016426,0.0002654026,0.0002673179,0.0008463721,0.0003234871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007728836,"about_ca_system_score_gemma":0.0001224106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009181782,"about_ca_topic_score_gemma":0.0001944731,"domain_scores_codex":[0.9998599,0.00004241173,0.00001054518,0.00001704377,0.00004869378,0.00002139985],"domain_scores_gemma":[0.9999442,0.000009798457,0.0000145774,0.000007257766,0.00001448151,0.000009762713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009178696,0.0002415509,0.0003455166,0.0006490391,0.00005825908,0.0004987554,0.0001189369,0.0007265071,0.8563442,0.003315269,0.00161003,0.1351741],"study_design_scores_gemma":[0.0004091622,0.005866747,0.003028185,0.0002075935,0.0002917824,0.005201135,0.0001807151,0.002485578,0.8718101,0.002558927,0.107914,0.00004605125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8306396,0.1266806,0.02910404,0.001777941,0.0008234452,0.0001527296,0.0002340129,0.0003116218,0.01027598],"genre_scores_gemma":[0.9532431,0.02921447,0.01000246,0.0008561312,0.0002087048,0.0000586281,0.0001481964,0.00003421267,0.00623421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001121018,"threshold_uncertainty_score":0.003750145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02700555963824746,"score_gpt":0.2953241612634984,"score_spread":0.268318601625251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}