{"id":"W3177742807","doi":"10.1158/1538-7445.am2021-ct002","title":"Abstract CT002: Phase 3 randomized trial comparing tebentafusp with investigator's choice in first line metastatic uveal melanoma","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Ocular Oncology and Treatments","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Clinical endpoint; Interim analysis; Population; Internal medicine; Randomized controlled trial; Ipilimumab; Intention-to-treat analysis; Oncology; Randomization; Progression-free survival; Surgery; Cancer; Chemotherapy; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001556093,0.001232235,0.001623118,0.0003224331,0.000360923,0.00103644,0.0008891425,0.001448952,0.012183],"category_scores_gemma":[0.001902221,0.0003280209,0.001386744,0.0004035939,0.0007970489,0.0008324347,0.0003229872,0.003025717,0.0009645118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009160274,"about_ca_system_score_gemma":0.001455189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001418688,"about_ca_topic_score_gemma":0.003349229,"domain_scores_codex":[0.9995081,0.0003219584,0.0000178557,0.00006124442,0.00003404873,0.00005669306],"domain_scores_gemma":[0.9988015,0.0003643455,0.0002762074,0.00006060544,0.00007045543,0.0004268729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9814693,0.004055233,0.0006279572,0.0004624931,0.0005302719,0.00004459859,0.00002926385,0.0003660666,0.002078328,0.0001175798,0.001796468,0.008422504],"study_design_scores_gemma":[0.9534248,0.04401672,0.001102814,0.00002413257,0.0002166697,0.00003309503,0.00001111108,0.0003799472,0.0001905043,0.0001190067,0.0004744027,0.000006835476],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769049,0.004588973,0.0008758634,0.001565973,0.0005443595,0.006971613,0.00350005,0.0002464069,0.004801801],"genre_scores_gemma":[0.9816836,0.001614963,0.001559178,0.001786889,0.0005291829,0.005332561,0.002328025,0.0000349024,0.005130646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.012183,"threshold_uncertainty_score":0.04075611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1539348520810326,"score_gpt":0.4672737265675273,"score_spread":0.3133388744864948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}