{"id":"W3177776093","doi":"","title":"Identification of Candidate Ciliopathy Genes Relevant to Childhood Blindness Syndromes by Genome-wide Screening of Knockout Mice","year":2021,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"","keywords":"Ciliopathy; Identification (biology); Blindness; Candidate gene; Biology; Genetics; Childhood blindness; Gene; Knockout mouse; Computational biology; Medicine; Phenotype; Optometry; Retinopathy of prematurity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003566242,0.0007885243,0.0005805715,0.001455713,0.0003866017,0.0003495279,0.0004913517,0.0005928908,0.002232373],"category_scores_gemma":[0.0003488001,0.0003116119,0.0007355304,0.0005639258,0.0004261266,0.0001045173,0.0003064078,0.0005631311,0.0003361481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000244476,"about_ca_system_score_gemma":0.0002937661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00138236,"about_ca_topic_score_gemma":0.002893124,"domain_scores_codex":[0.9997693,0.00003341769,0.00002868109,0.00006596365,0.00005614024,0.00004647336],"domain_scores_gemma":[0.9996812,0.000137735,0.0001025819,0.00001849792,0.00001724304,0.00004263683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002982954,0.0000475665,0.002547008,0.00006237436,0.00007308648,0.0007772745,0.00005099749,0.0002156296,0.9936607,0.0002260447,0.0001217678,0.001919233],"study_design_scores_gemma":[0.0003430826,0.0007221287,0.148151,0.00007904901,0.001230458,0.01085208,0.0002869278,0.004759704,0.8230153,0.0003825787,0.01011975,0.00005802563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832481,0.001293816,0.01021746,0.0001779561,0.00003362823,0.0001185676,0.003591509,0.0002397723,0.001079099],"genre_scores_gemma":[0.980353,0.001405872,0.01209503,0.000169912,0.0000157847,0.0001490569,0.004032533,0.0001223702,0.001656426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002232373,"threshold_uncertainty_score":0.007468045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01637535282689719,"score_gpt":0.2948842355263497,"score_spread":0.2785088826994525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}