{"id":"W3177811450","doi":"10.1186/s12711-021-00651-0","title":"A conditional multi-trait sequence GWAS discovers pleiotropic candidate genes and variants for sheep wool, skin wrinkle and breech cover traits","year":2021,"lang":"en","type":"article","venue":"Genetics Selection Evolution","topic":"Hair Growth and Disorders","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Australian Wool Innovation","keywords":"Biology; Genome-wide association study; Candidate gene; Genetics; Pleiotropy; Quantitative trait locus; Gene; Genetic association; Wool; Genetic architecture; Trait; Computational biology; Single-nucleotide polymorphism; Genotype; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007442982,0.0001572029,0.0001861747,0.0001000068,0.0002166761,0.00003272769,0.00002727819,0.0001360086,0.00006908203],"category_scores_gemma":[0.00009213715,0.0001683274,0.00004988941,0.0002319365,0.00009968028,0.0001211574,0.00002116516,0.0001072335,0.000004576517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001306729,"about_ca_system_score_gemma":0.0003558701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001043472,"about_ca_topic_score_gemma":0.0005843611,"domain_scores_codex":[0.998899,0.00004187802,0.0002068866,0.0003875076,0.0001836216,0.0002810571],"domain_scores_gemma":[0.9994414,0.00003583785,0.00007411195,0.00008409371,0.0002018964,0.0001626298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007858292,0.0006203809,0.2279247,0.0007994518,0.0004208777,0.00002911409,0.0008526141,0.003219591,0.7300374,0.004445957,0.002145674,0.02871845],"study_design_scores_gemma":[0.005636812,0.0004622958,0.930844,0.00004483385,0.0002483591,0.000513516,0.0002280541,0.04697143,0.0108303,0.001541989,0.002373491,0.0003049137],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7778512,0.001354078,0.2196189,0.0002998228,0.000127273,0.0004184763,0.0002164352,0.00003859436,0.00007522493],"genre_scores_gemma":[0.991551,0.0003759499,0.006744363,0.0002140314,0.0001417229,0.00005294928,0.0003488474,0.00002082674,0.0005502381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7192071,"threshold_uncertainty_score":0.686419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01759240829369468,"score_gpt":0.271846784036037,"score_spread":0.2542543757423423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}