{"id":"W3177818426","doi":"10.1158/1538-7445.am2021-284","title":"Abstract 284: Design, synthesis and biological evaluation of novel water-soluble salts of the antimitotic prodrugs 4-(3-alkyl-2-oxoimidazolidin-1-yl)-<i>N</i>-phenylbenzenesulfonamides selectively bioactivated by cytochrome p450 1A1 in breast cancer cells","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Chemistry; Prodrug; Solubility; Sulforhodamine B; Aqueous solution; Context (archaeology); Alkyl; Salt (chemistry); Combinatorial chemistry; Stereochemistry; In vitro; Cytotoxicity; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001282134,0.000276487,0.000278242,0.0001043736,0.00008515854,0.0001577091,0.0002172994,0.0002503779,0.0008663054],"category_scores_gemma":[0.0001278597,0.0001027263,0.0001691843,0.0001077504,0.00009502176,0.0001354714,0.0001044088,0.0002154082,0.0004308525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002308608,"about_ca_system_score_gemma":0.0002322894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005552081,"about_ca_topic_score_gemma":0.000711805,"domain_scores_codex":[0.9999232,0.00001304044,0.0000100634,0.00001583294,0.00002857046,0.000009310353],"domain_scores_gemma":[0.9999446,0.000005525196,0.00001731755,0.000004084941,0.0000160116,0.0000125152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008807159,0.00004862597,0.00006685587,0.00004564852,0.000003161336,0.00002102235,0.000006764565,0.0002011638,0.9976671,0.00004983173,0.00002985993,0.001771811],"study_design_scores_gemma":[0.00003511046,0.001171893,0.0004591346,0.000002645704,0.000009044862,0.00005009156,0.000003632353,0.0004824773,0.9963181,0.000007493607,0.001457994,0.000002394521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934789,0.00117882,0.003284933,0.00005454967,0.00003123008,0.0001564165,0.0002624086,0.00004953096,0.001503113],"genre_scores_gemma":[0.9880975,0.001106234,0.005837001,0.00004033521,0.00001038862,0.00008660737,0.0007114962,0.00002401878,0.004086496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008663054,"threshold_uncertainty_score":0.002898037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07286993358995593,"score_gpt":0.3455121928686281,"score_spread":0.2726422592786722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}