{"id":"W3177859492","doi":"10.1158/1538-7445.am2021-359","title":"Abstract 359: Molecular signatures associated with long-term response to apalutamide (APA) in patients (pts) with metastatic castration-sensitive prostate cancer (mCSPC) in TITAN","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Prevention of Organ Failure","funders":"","keywords":"Quartile; Prostate cancer; Internal medicine; Medicine; Cohort; Oncology; Population; Proportional hazards model; Androgen deprivation therapy; Hazard ratio; Placebo; Cancer; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001722071,0.0001132249,0.0002308925,0.000202734,0.0001462062,0.0002601522,0.0001272709,0.0001240012,0.0008069632],"category_scores_gemma":[0.0002719769,0.00006671315,0.0002136385,0.0003403396,0.000166092,0.0001329835,0.0001867582,0.0002415976,0.0001210559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002747345,"about_ca_system_score_gemma":0.0002608782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009818751,"about_ca_topic_score_gemma":0.002255927,"domain_scores_codex":[0.9999154,0.00002358865,0.000005656575,0.00002167938,0.000016988,0.0000166854],"domain_scores_gemma":[0.9998395,0.00002606079,0.0000649759,0.00001037782,0.00001578833,0.00004326054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01006675,0.0004565517,0.9260479,0.00008543837,0.0002059741,0.0002189651,0.0001415784,0.0005229338,0.04076126,0.00005459947,0.0005177498,0.02092033],"study_design_scores_gemma":[0.0001138259,0.001656852,0.9955243,0.00000304416,0.000062011,0.0002221275,0.00007232308,0.0007505905,0.001138503,0.00003662723,0.0004155659,0.000004303767],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996202,0.00005974567,0.00003372616,0.00001784496,0.000001229383,0.000007120838,0.0001625869,0.000002042756,0.00009557097],"genre_scores_gemma":[0.9993154,0.00002128408,0.00007806208,0.00001964455,0.000002609196,0.000009849125,0.0004000302,9.034666e-7,0.0001522896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009818751,"threshold_uncertainty_score":0.002699554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03875657874232862,"score_gpt":0.3861827067174622,"score_spread":0.3474261279751336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}