{"id":"W3177908368","doi":"10.1158/1538-7445.am2021-928","title":"Abstract 928: Glypican-3 targeted thorium-227 alpha therapy reduces tumor burden in an orthotopic xenograft model of hepatocellular carcinoma","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Glypican 3; Biodistribution; In vivo; Radioimmunotherapy; Antibody; Hepatocellular carcinoma; Cancer research; Medicine; Flow cytometry; Cancer; Monoclonal antibody; Chemistry; Immunology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000126349,0.0003839651,0.0003229672,0.0002203583,0.0001077175,0.0001673214,0.0001673794,0.0002656808,0.001565564],"category_scores_gemma":[0.00005529543,0.0001085179,0.000172521,0.0001650439,0.0001633463,0.0002084329,0.00009805647,0.0005342939,0.0004725422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002645348,"about_ca_system_score_gemma":0.0002269005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001499478,"about_ca_topic_score_gemma":0.001266239,"domain_scores_codex":[0.9998969,0.00001855911,0.000006625823,0.00001665478,0.00003666027,0.00002450583],"domain_scores_gemma":[0.9999423,0.000007622565,0.00001536975,0.000008373977,0.000009819963,0.00001648902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002471302,0.0000600767,0.00007507647,0.0000190203,0.000003802563,0.00002377321,0.000006655248,0.00005938715,0.9986603,0.00003056726,0.00006006937,0.0007540436],"study_design_scores_gemma":[0.00002402758,0.000722073,0.001169184,0.000001605352,0.00001203249,0.0001464894,0.000009582791,0.0005815523,0.9964999,0.00001032996,0.0008208878,0.000002453965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945156,0.0007439106,0.002531663,0.0000970605,0.00003516244,0.0000410982,0.0003002091,0.0001485136,0.001586775],"genre_scores_gemma":[0.9902647,0.000551654,0.002624911,0.0000484814,0.00001111963,0.00005275727,0.000588994,0.00005389677,0.005803643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001565564,"threshold_uncertainty_score":0.005237401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1429817789860703,"score_gpt":0.4160329136280503,"score_spread":0.27305113464198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}